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PMID:8875886

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Citation

Sweet, HO, Bronson, RT, Johnson, KR, Cook, SA and Davisson, MT (1996) Scrambler, a new neurological mutation of the mouse with abnormalities of neuronal migration. Mamm. Genome 7:798-802

Abstract

A novel spontaneous neurological mutation, scrambler (scm), appeared in the inbred mouse strain DC/Le (dancer) in 1991. Mice homozygous for this recessive mutation are recognized by an unstable gait and whole-body tremor. The cerebella of 30-day-old scrambler homozygotes are hypoplastic and devoid of folia; however, neither seizures nor abnormal brain wave patterns have been observed. Homozygous scrambler mutants have an ataxic gait which in the male may be a contributory factor in the failure to mate. Female homozygotes mate and breed. Life span is not reduced in either sex. Scrambler is similar to the reeler mutation in phenotype and pathology and, like reeler, probably results from defective neuronal migration. We mapped the scrambler mutation to Chromosome (Chr) 4, proving that it is distinct from the recently cloned reeler gene on Chr 5. We also determined the map position of the agrin gene, Agrn, on Chr 4, and on this basis eliminated it as a candidate for scm. Currently there is no known homology of scrambler with human lissencephalies or other human disorders caused by abnormal neuronal migration.

Links

PubMed

Keywords

Agrin/genetics; Animals; Brain/abnormalities; Brain/pathology; Brain/physiology; Cell Movement; Cerebellum/abnormalities; Cerebellum/pathology; Cerebral Cortex/abnormalities; Cerebral Cortex/pathology; Chromosome Mapping; Crosses, Genetic; Dinucleotide Repeats; Female; Genetic Markers; Humans; Male; Mice; Mice, Neurologic Mutants; Microsatellite Repeats; Neurons/pathology; Neurons/physiology; Polymerase Chain Reaction; Recombination, Genetic

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:DAB1

acts_upstream_of_or_within

GO:0001764: neuron migration

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1856801

P

  • occurs_in:(EMAPA:17787)
  • results_in_movement_of:(CL:0000540)|occurs_in(EMAPA:32845)
  • results_in_movement_of:(CL:0000540)

Seeded From UniProt

complete

MOUSE:DAB1

acts_upstream_of_or_within

GO:0007628: adult walking behavior

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1856801

P

Seeded From UniProt

complete


See also

References

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