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PMID:8752214

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Citation

Zimmerman, LB, De Jesús-Escobar, JM and Harland, RM (1996) The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell 86:599-606

Abstract

Signals released by the Spemann organizer of the amphibian gastrula can directly induce neural tissue from ectoderm and can dorsalize ventral mesoderm to form muscle. The secreted polypeptide noggin mimics these activities and is expressed at the appropriate time and place to participate in the organizer signal. Neural induction and mesoderm dorsalization are antagonized by bone morphogenetic proteins (BMPs), which induce epidermis and ventral mesoderm instead. Here we report that noggin protein binds BMP4 with high affinity and can abolish BMP4 activity by blocking binding to cognate cell-surface receptors. These data suggest that noggin secreted by the organizer patterns the embryo by interrupting BMP signaling.

Links

PubMed

Keywords

Animals; Base Sequence; Bone Marrow Cells; Bone Morphogenetic Protein Receptors; Bone Morphogenetic Proteins; Carrier Proteins; Cells, Cultured; DNA Primers/chemistry; Immunologic Techniques; Mice; Molecular Sequence Data; Protein Binding; Proteins/antagonists & inhibitors; Proteins/metabolism; Proteins/physiology; Receptors, Cell Surface/metabolism; Receptors, Growth Factor; Signal Transduction; Xenopus laevis/embryology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:BMP2

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q13253

F

Seeded From UniProt

complete

HUMAN:BMP4

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q13253

F

Seeded From UniProt

complete

HUMAN:NOGG

involved_in

GO:0030514: negative regulation of BMP signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:NOGG

enables

GO:0019955: cytokine binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P12644

F

Seeded From UniProt

complete

HUMAN:NOGG

enables

GO:0019955: cytokine binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P12643

F

Seeded From UniProt

complete

HUMAN:NOGG

involved_in

GO:0060302: negative regulation of cytokine activity

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

XENLA:NOGG

involved_in

GO:0030514: negative regulation of BMP signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

XENLA:NOGG

GO:0030514: negative regulation of BMP signaling pathway

ECO:0000314:

P

Fig 1 shows noggins role in negative regulation of signal transduction.

complete
CACAO 2096


See also

References

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