GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:8684459

From GONUTS
Jump to: navigation, search
Citation

Yang, XJ, Ogryzko, VV, Nishikawa, J, Howard, BH and Nakatani, Y (1996) A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature 382:319-24

Abstract

The adenoviral oncoprotein E1A induces progression through the cell cycle by binding to the products of the p300/CBP and retinoblastoma gene families. A new cellular p300/CBP-associated factor (P/CAF) having intrinsic histone acetylase activity has been identified that competes with E1A. Exogenous expression of P/CAF in HeLa cells inhibits cell-cycle progression and counteracts the mitogenic activity of E1A. E1A disturbs the normal cellular interaction between p300/CBP and its associated histone acetylase.

Links

PubMed Online version:10.1038/382319a0

Keywords

Acetyltransferases/genetics; Acetyltransferases/metabolism; Adenovirus E1A Proteins/metabolism; Amino Acid Sequence; Binding, Competitive; Cell Cycle; Cell Cycle Proteins/genetics; Cell Cycle Proteins/metabolism; Cloning, Molecular; Escherichia coli; HeLa Cells; Histone Acetyltransferases; Humans; Molecular Sequence Data; Nuclear Proteins/metabolism; Protein Binding; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Saccharomyces cerevisiae Proteins; Sequence Deletion; Trans-Activators; Transcription Factors/metabolism; p300-CBP Transcription Factors

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:EP300

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q92831

F

Seeded From UniProt

complete

HUMAN:EP300

enables

GO:0001221: transcription coregulator binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q92831

F

Seeded From UniProt

complete

HUMAN:CBP

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q92831

F

Seeded From UniProt

complete

HUMAN:CBP

enables

GO:0003713: transcription coactivator activity

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q92793

F

Seeded From UniProt

complete

HUMAN:KAT2B

involved_in

GO:0051726: regulation of cell cycle

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:KAT2B

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q09472

F

Seeded From UniProt

complete

HUMAN:KAT2B

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q92793

F

Seeded From UniProt

complete

HUMAN:KAT2B

enables

GO:0016407: acetyltransferase activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:KAT2B

involved_in

GO:0008285: negative regulation of cell population proliferation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:KAT2B

enables

GO:0003712: transcription coregulator activity

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q92793

F

Seeded From UniProt

complete

HUMAN:KAT2B

enables

GO:0003712: transcription coregulator activity

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q09472

F

Seeded From UniProt

complete

HUMAN:KAT2B

involved_in

GO:0007050: cell cycle arrest

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:KAT2B

involved_in

GO:0006473: protein acetylation

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:KAT2B

involved_in

GO:0006338: chromatin remodeling

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:Q4LE28

enables

GO:0003713: transcription coactivator activity

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q92793

F

Seeded From UniProt

complete

HUMAN:EP300

enables

GO:0008134: transcription factor binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q92831

F

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.