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PMID:8654926

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Citation

Zhang, SD, Kassis, J, Olde, B, Mellerick, DM and Odenwald, WF (1996) Pollux, a novel Drosophila adhesion molecule, belongs to a family of proteins expressed in plants, yeast, nematodes, and man. Genes Dev. 10:1108-19

Abstract

Adhesion molecules have pivotal roles in cellular processes critical to the development and maintenance of multicellular organisms. Here we describe a new member of the adhesive repertoire encoded by the Drosophila pollux (plx) gene. Marked by a novel 74-amino-acid domain, Plx belongs to a highly conserved family with members in plants, yeast, nematodes, and man, including the human oncoprotein TRE17. Essential for viability, plx mutant analysis indicates that larval death is attributable to asphyxiation brought on by fluid-congested tracheal tubes. Ultrastructural examination of mutant tracheae reveals defects in cell-extracellular matrix contacts. During embryogenesis, Plx uniformly covers the apical surface of cellular blastoderm cells. It is later found regionally concentrated along subsets of central nervous system axon pathways and on the apical surface of the trachea's tubular epithelium. Cell attachment assays demonstrate that Plx can serve as a ligand for cell surface integrins. Plx also contains a motor neuron-selective adhesive site, multiple proteoglycan-binding motifs, and a leucine zipper: all suggest possible associations with additional components of the adhesion complex.

Links

PubMed

Keywords

Amino Acid Sequence; Animals; Arabidopsis/genetics; Blastoderm/chemistry; Caenorhabditis elegans/genetics; Cell Adhesion/physiology; Cell Adhesion Molecules/genetics; Cell Adhesion Molecules/metabolism; Cell Adhesion Molecules/physiology; Central Nervous System/chemistry; Central Nervous System/embryology; DNA, Complementary/genetics; Drosophila/embryology; Drosophila/genetics; Drosophila Proteins; Embryo, Nonmammalian/chemistry; Gene Expression; Gene Expression Regulation, Developmental; Hominidae/genetics; Humans; Larva; Leucine Zippers; Molecular Sequence Data; Oryza sativa/genetics; RNA, Messenger/analysis; Receptors, Immunologic/metabolism; Receptors, Peptide/metabolism; Sequence Homology, Amino Acid; Trachea/chemistry; Trachea/embryology; Trachea/pathology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:A0A0B4KG76

enables

GO:0005178: integrin binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

DROME:A0A0B4KG76

involved_in

GO:0033627: cell adhesion mediated by integrin

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:A0A0B4KG76

located_in

GO:0009986: cell surface

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:A0A0B4KGK7

enables

GO:0005178: integrin binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

DROME:A0A0B4KGK7

involved_in

GO:0033627: cell adhesion mediated by integrin

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:A0A0B4KGK7

located_in

GO:0009986: cell surface

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:E1JJ52

enables

GO:0005178: integrin binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

DROME:E1JJ52

involved_in

GO:0033627: cell adhesion mediated by integrin

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:E1JJ52

located_in

GO:0009986: cell surface

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:Q24193

enables

GO:0005178: integrin binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

DROME:Q24193

involved_in

GO:0033627: cell adhesion mediated by integrin

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q24193

located_in

GO:0009986: cell surface

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:Q6AWQ6

enables

GO:0005178: integrin binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

DROME:Q6AWQ6

involved_in

GO:0033627: cell adhesion mediated by integrin

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q6AWQ6

located_in

GO:0009986: cell surface

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:Q8IPP5

enables

GO:0005178: integrin binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

DROME:Q8IPP5

involved_in

GO:0033627: cell adhesion mediated by integrin

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8IPP5

located_in

GO:0009986: cell surface

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:Q9TY11

enables

GO:0005178: integrin binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

DROME:Q9TY11

involved_in

GO:0033627: cell adhesion mediated by integrin

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9TY11

located_in

GO:0009986: cell surface

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:Q9VNG9

enables

GO:0005178: integrin binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

DROME:Q9VNG9

involved_in

GO:0033627: cell adhesion mediated by integrin

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VNG9

located_in

GO:0009986: cell surface

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete


See also

References

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