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PMID:8553073

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Citation

Kessler, E, Takahara, K, Biniaminov, L, Brusel, M and Greenspan, DS (1996) Bone morphogenetic protein-1: the type I procollagen C-proteinase. Science 271:360-2

Abstract

Bone morphogenetic proteins (BMPs) are bone-derived factors capable of inducing ectopic bone formation. Unlike other BMPs, BMP-1 is not like transforming growth factor-beta (TGF-beta), but it is the prototype of a family of putative proteases implicated in pattern formation during development in diverse organisms. Although some members of this group, such as Drosophila tolloid (TLD), are postulated to activate TGF-beta-like proteins, actual substrates are unknown. Procollagen C-proteinase (PCP) cleaves the COOH-propeptides of procollagens I, II, and III to yield the major fibrous components of vertebrate extracellular matrix. Here it is shown that BMP-1 and PCP are identical. This demonstration of enzymatic activity for a BMP-1/TLD-like protein links an enzyme involved in matrix deposition to genes involved in pattern formation.

Links

PubMed

Keywords

Amino Acid Sequence; Animals; Bone Morphogenetic Protein 1; Bone Morphogenetic Proteins; Humans; Metalloendopeptidases/chemistry; Metalloendopeptidases/metabolism; Mice; Molecular Sequence Data; Molecular Weight; Peptide Fragments/metabolism; Procollagen/metabolism; Proteins/chemistry; Proteins/metabolism; Recombinant Proteins/chemistry; Recombinant Proteins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:BMP1

enables

GO:0008233: peptidase activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete


See also

References

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