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PMID:8538742

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Citation

Turton, MD, O'Shea, D, Gunn, I, Beak, SA, Edwards, CM, Meeran, K, Choi, SJ, Taylor, GM, Heath, MM, Lambert, PD, Wilding, JP, Smith, DM, Ghatei, MA, Herbert, J and Bloom, SR (1996) A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379:69-72

Abstract

The sequence of glucagon-like peptide-1 (7-36) amide (GLP-1) is completely conserved in all mammalian species studied, implying that it plays a critical physiological role. We have shown that GLP-1 and its specific receptors are present in the hypothalamus. No physiological role for central GLP-1 has been established. We report here that intracerebroventricular (ICV) GLP-1 powerfully inhibits feeding in fasted rats. ICV injection of the specific GLP-1-receptor antagonist, exendin (9-39), blocked the inhibitory effect of GLP-1 on food intake. Exendin (9-39) alone had no influence on fast-induced feeding but more than doubled food intake in satiated rats, and augmented the feeding response to the appetite stimulant, neuropeptide Y. Induction of c-fos is a marker of neuronal activation. Following ICV GLP-1 injection, c-fos appeared exclusively in the paraventricular nucleus of the hypothalamus and central nucleus of the amygdala, and this was inhibited by prior administration of exendin (9-39). Both of these regions of the brain are of primary importance in the regulation of feeding. These findings suggest that central GLP-1 is a new physiological mediator of satiety.

Links

PubMed Online version:10.1038/379069a0

Keywords

Animals; Cerebral Ventricles/physiology; Eating/physiology; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Injections, Intraventricular; Male; Neuropeptide Y/pharmacology; Peptide Fragments/administration & dosage; Peptide Fragments/antagonists & inhibitors; Peptide Fragments/pharmacology; Peptide Fragments/physiology; Proto-Oncogene Proteins c-fos/metabolism; Rats; Satiation/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:GLUC

involved_in

GO:0007631: feeding behavior

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete


See also

References

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