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PMID:8350650

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Citation

Ishi, N, Suzuki, N, Hartman, PS and Suzuki, K (1993) The radiation-sensitive mutant rad-8 of Caenorhabditis elegans is hypersensitive to the effects of oxygen on aging and development. Mech. Ageing Dev. 68:1-10

Abstract

A mutant of rad-8, originally isolated on the basis of its hypersensitivity to ultraviolet radiation, is also hypersensitive to oxygen and methyl viologen, a superoxide-anion generator. Oxygen also retarded development and reduced fecundity in a concentration-dependent fashion in rad-8 but not in wild type. In addition, the mean life span of rad-8 (but not wild type) was progressively shortened when animals incubated in increasing oxygen concentrations. This cross hypersensitivity to both UV radiation and free radicals provides further evidence that DNA damage may be important in the aging process.

Links

PubMed

Keywords

Aging/drug effects; Animals; Caenorhabditis elegans/drug effects; Caenorhabditis elegans/genetics; Caenorhabditis elegans/growth & development; Caenorhabditis elegans/radiation effects; Fertility/drug effects; Longevity/drug effects; Mutation; Oxygen/toxicity; Paraquat/toxicity; Radiation Tolerance/genetics; Survival Rate

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CAEEL:RT4I1

involved_in

GO:0000303: response to superoxide

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00089079

P

Seeded From UniProt

complete

CAEEL:RT4I1

involved_in

GO:0032504: multicellular organism reproduction

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00089079

P

Seeded From UniProt

complete

CAEEL:RT4I1

involved_in

GO:0070482: response to oxygen levels

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00089079

P

Seeded From UniProt

complete

CAEEL:RT4I1

involved_in

GO:0040014: regulation of multicellular organism growth

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00089079

P

Seeded From UniProt

complete

CAEEL:RT4I1

involved_in

GO:0040010: positive regulation of growth rate

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00089079

P

Seeded From UniProt

complete


See also

References

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