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PMID:8259520
Citation |
Liu, H, Styles, CA and Fink, GR (1993) Elements of the yeast pheromone response pathway required for filamentous growth of diploids. Science 262:1741-4 |
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Abstract |
Transmission of an external signal from receptors to downstream targets is often mediated by a conserved set of protein kinases that act in sequence (a kinase cascade). In haploid strains of Saccharomyces cerevisiae, a signal initiated by peptide pheromones is transmitted through this kinase cascade to a transcription factor STE12, which is required for the expression of many mating-specific genes. Here it was shown that in diploids some of the same kinases and STE12 are required for filamentous growth, but the pheromone receptors and guanosine triphosphate-binding protein are not required for filament formation. Thus, a similar kinase cascade is activated by different signals in haploids and diploids and mediates different developmental outcomes in the two cell types. |
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Keywords |
Fungal Proteins/metabolism; GTP-Binding Proteins/metabolism; Genes, Fungal; Mutation; Peptides/metabolism; Peptides/pharmacology; Phenotype; Protein Kinases/metabolism; Receptors, Mating Factor; Receptors, Peptide/metabolism; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/growth & development; Saccharomyces cerevisiae/metabolism; Saccharomyces cerevisiae Proteins; Signal Transduction; Transcription Factors/metabolism |
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Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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