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PMID:820683

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Citation

Holden, JA, Harriman, PD and Wall, JD (1976) Escherichia coli mutants deficient in guanine-xanthine phosphoribosyltransferase. J. Bacteriol. 126:1141-8

Abstract

We studied the purine phosphoribosyltransferases (PRTases) of Escherichia coli and were able to isolate a mutant that is defective in its ability to convert guanine and xanthine to their respective ribonucleotides. The affected gene (gpt) lies between metD and proA and is 78.6% co-transducible with proA. Both this point mutant and a strain with a pro-lac deletion contain less than 2% of wild-type xanthine PRTase activity, yet still contain about 30% of wild-type guanine PRTase activity. Thus, the gpt gene is only one of at least two genes responsible for guanine PRTase activity in E. coli.

Links

PubMed PMC233137

Keywords

Adenine/metabolism; Cell-Free System; Escherichia coli/enzymology; Escherichia coli/metabolism; Genes; Guanine/metabolism; Hypoxanthines/metabolism; Mutation; Pentosyltransferases/biosynthesis; Purine Nucleotides/biosynthesis; Purine-Nucleoside Phosphorylase/biosynthesis; Xanthines/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

ECOLI:XGPT

acts_upstream_of_or_within

GO:0032263: GMP salvage

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ECOLI:XGPT

acts_upstream_of_or_within

GO:0032265: XMP salvage

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ECOLI:XGPT

involved_in

GO:0032263: GMP salvage

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ECOLI:XGPT

involved_in

GO:0032265: XMP salvage

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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