GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:8078582

From GONUTS
Jump to: navigation, search
Citation

Tsai, FY, Keller, G, Kuo, FC, Weiss, M, Chen, J, Rosenblatt, M, Alt, FW and Orkin, SH (1994) An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature 371:221-6

Abstract

Blood cell development relies on the expansion and maintenance of haematopoietic stem and progenitor cells in the embryo. By gene targeting in mouse embryonic stem cells, we demonstrate that the transcription factor GATA-2 plays a critical role in haematopoiesis, particularly of an adult type. We propose that GATA-2 regulates genes controlling growth factor responsiveness or the proliferative capacity of early haematopoietic cells.

Links

PubMed Online version:10.1038/371221a0

Keywords

Anemia/embryology; Animals; Base Sequence; Bone Marrow/embryology; Bone Marrow Cells; Cells, Cultured; DNA Primers; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Erythrocytes/cytology; Female; Fetal Death; GATA2 Transcription Factor; Gene Expression Regulation; Genes, Lethal; Hematopoiesis/genetics; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mutagenesis; Restriction Mapping; Spleen/cytology; Spleen/embryology; Stem Cells; Transcription Factors/genetics; Transcription Factors/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:GATA2

acts_upstream_of_or_within

GO:0060216: definitive hemopoiesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857743

P

  • occurs_in:(EMAPA:16846)

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.