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PMID:7923373

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Citation

Georgopoulos, K, Bigby, M, Wang, JH, Molnar, A, Wu, P, Winandy, S and Sharpe, A (1994) The Ikaros gene is required for the development of all lymphoid lineages. Cell 79:143-56

Abstract

The Ikaros gene encodes a family of early hematopoietic- and lymphocyte-restricted transcription factors. Mice homozygous for a germline mutation in the Ikaros DNA-binding domain lack not only T and B lymphocytes and natural killer cells but also their earliest defined progenitors. In contrast, the erythroid and myeloid lineages were intact in these mutant mice. We propose that Ikaros promotes differentiation of pluripotential hematopoietic stem cell(s) into the lymphocyte pathways. In the absence of a functional Ikaros gene, these stem cells are exclusively diverted into the erythroid and myeloid lineages.

Links

PubMed

Keywords

Animals; Base Sequence; Bone Marrow Cells; Cell Differentiation; Cloning, Molecular; DNA/metabolism; DNA-Binding Proteins; Epidermis/cytology; Gene Expression Regulation, Developmental; Gene Targeting; Germ-Line Mutation; Hematopoietic Stem Cells/cytology; Ikaros Transcription Factor; Killer Cells, Natural/cytology; Lymph Nodes; Lymphocytes/cytology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Molecular Sequence Data; Protein Binding; RNA, Messenger/analysis; Spleen/cytology; Spleen/pathology; Thymus Gland/cytology; Transcription Factors/genetics; Transcription Factors/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:IKZF1

acts_upstream_of_or_within

GO:0030217: T cell differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2158738

P

Seeded From UniProt

complete

MOUSE:IKZF1

acts_upstream_of_or_within

GO:0030183: B cell differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2158738

P

Seeded From UniProt

complete

MOUSE:IKZF1

acts_upstream_of_or_within

GO:0001779: natural killer cell differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2158738

P

Seeded From UniProt

complete

MOUSE:IKZF1

enables

GO:0043565: sequence-specific DNA binding

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2158738

F

Seeded From UniProt

complete

MOUSE:IKZF1

acts_upstream_of_or_within

GO:0048541: Peyer's patch development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2158738

P

Seeded From UniProt

complete

MOUSE:IKZF1

acts_upstream_of_or_within

GO:0048538: thymus development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2158738

P

Seeded From UniProt

complete

MOUSE:IKZF1

acts_upstream_of_or_within

GO:0048535: lymph node development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2158738

P

Seeded From UniProt

complete


See also

References

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