GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:7885444

From GONUTS
Jump to: navigation, search
Citation

Noakes, PG, Gautam, M, Mudd, J, Sanes, JR and Merlie, JP (1995) Aberrant differentiation of neuromuscular junctions in mice lacking s-laminin/laminin beta 2. Nature 374:258-62

Abstract

Synapse formation requires a complex interchange of information between the pre- and postsynaptic partners. At the skeletal neuromuscular junction, some of this information is contained in the basal lamina (BL), which runs through the synaptic cleft between the motor nerve terminal and the muscle fibre. During regeneration following injury, components of synaptic BL can trigger several features of postsynaptic differentiation in the absence of the nerve terminal, and of presynaptic differentiation in the absence of the muscle fibre. One nerve-derived component of synaptic BL, agrin, is known to affect postsynaptic differentiation, but no muscle-derived components have yet been shown to influence motor nerve terminals. A candidate for such a role is s-laminin (also called laminin beta 2), a homologue of the B1 (beta 1) chain of the widely distributed BL glycoprotein, laminin. s-Laminin is synthesized by muscle cells and concentrated in synaptic BL. In vitro, recombinant s-laminin fragments are selectively adhesive for motor neuron-like cells, inhibit neurite outgrowth promoted by other matrix molecules, and act as a 'stop signal' for growing neurites. By generating and characterizing mice with a targeted mutation of the s-laminin gene, we show here that s-laminin regulates formation of motor nerve terminals.

Links

PubMed Online version:10.1038/374258a0

Keywords

Action Potentials; Animals; Cell Differentiation/genetics; Laminin/deficiency; Laminin/genetics; Laminin/physiology; Mice; Motor Neurons/physiology; Motor Neurons/ultrastructure; Mutation; Neuromuscular Junction/embryology; Neuromuscular Junction/ultrastructure

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:F7CK55

located_in

GO:0031594: neuromuscular junction

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32716)

Seeded From UniProt

complete

MOUSE:F7CK55

located_in

GO:0005604: basement membrane

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32716)

Seeded From UniProt

complete

MOUSE:ACES

located_in

GO:0031594: neuromuscular junction

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32716)

Seeded From UniProt

complete

MOUSE:ACES

located_in

GO:0005604: basement membrane

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32716)

Seeded From UniProt

complete

MOUSE:P70165

located_in

GO:0031594: neuromuscular junction

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32716)

Seeded From UniProt

complete

MOUSE:P70165

located_in

GO:0005604: basement membrane

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32716)

Seeded From UniProt

complete

MOUSE:Q3TP61

located_in

GO:0031594: neuromuscular junction

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32716)

Seeded From UniProt

complete

MOUSE:Q3TP61

located_in

GO:0005604: basement membrane

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32716)

Seeded From UniProt

complete

MOUSE:LAMB2

acts_upstream_of_or_within

GO:0007528: neuromuscular junction development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2138070

P

Seeded From UniProt

complete

MOUSE:Q61436

located_in

GO:0031594: neuromuscular junction

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32716)

Seeded From UniProt

complete

MOUSE:Q61436

located_in

GO:0005604: basement membrane

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32716)

Seeded From UniProt

complete

MOUSE:Q63ZW6

located_in

GO:0031594: neuromuscular junction

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32716)

Seeded From UniProt

complete

MOUSE:Q63ZW6

located_in

GO:0005604: basement membrane

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32716)

Seeded From UniProt

complete

MOUSE:Q80V57

located_in

GO:0031594: neuromuscular junction

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32716)

Seeded From UniProt

complete

MOUSE:Q80V57

located_in

GO:0005604: basement membrane

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32716)

Seeded From UniProt

complete

MOUSE:Q8BNS7

located_in

GO:0031594: neuromuscular junction

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32716)

Seeded From UniProt

complete

MOUSE:Q8BNS7

located_in

GO:0005604: basement membrane

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32716)

Seeded From UniProt

complete

MOUSE:Q9ESQ2

located_in

GO:0031594: neuromuscular junction

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32716)

Seeded From UniProt

complete

MOUSE:Q9ESQ2

located_in

GO:0005604: basement membrane

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32716)

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.