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PMID:7854420

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Citation

Varnum, BC, Young, C, Elliott, G, Garcia, A, Bartley, TD, Fridell, YW, Hunt, RW, Trail, G, Clogston, C and Toso, RJ (1995) Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6. Nature 373:623-6

Abstract

The Axl receptor tyrosine kinase was identified as a protein encoded by a transforming gene from primary human myeloid leukaemia cells by DNA-mediated transformation of NIH 3T3 cells. Axl is the founding member of a family of related receptors that includes Eyk, encoded by a chicken proto-oncogene originally described as a retroviral transforming gene, and c-Mer, encoded by a human proto-oncogene expressed in neoplastic B- and T-cell lines. The transforming activity of Axl demonstrates that the receptor can drive cellular proliferation. The function of Axl in non-transformed cells and tissues is unknown, but may involve the stimulation of cell proliferation in response to an appropriate signal, namely a ligand that activates the receptor. We report here the purification of an Axl stimulatory factor, and its identification as the product of growth-arrest-specific gene 6 (ref. 6). This is, to our knowledge, the first description of a ligand for the Axl family of receptors.

Links

PubMed Online version:10.1038/373623a0

Keywords

Amino Acid Sequence; Animals; CHO Cells; Cricetinae; Cross-Linking Reagents; Enzyme Activation; Humans; Intercellular Signaling Peptides and Proteins; Ligands; Molecular Sequence Data; Oncogene Proteins/metabolism; Protein Binding; Proteins/isolation & purification; Proteins/metabolism; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases/metabolism; Recombinant Proteins; Tumor Cells, Cultured; Vitamin K/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:UFO

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q14393

F

Seeded From UniProt

complete

HUMAN:GAS6

involved_in

GO:0001934: positive regulation of protein phosphorylation

ECO:0000314: direct assay evidence used in manual assertion

P

  • has_input:(UniProtKB:P30530)

Seeded From UniProt

complete

HUMAN:GAS6

involved_in

GO:0007165: signal transduction

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:GAS6

enables

GO:0005102: signaling receptor binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P30530

F

Seeded From UniProt

complete

HUMAN:GAS6

involved_in

GO:0048146: positive regulation of fibroblast proliferation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:GAS6

involved_in

GO:0045860: positive regulation of protein kinase activity

ECO:0000314: direct assay evidence used in manual assertion

P

  • has_input:(UniProtKB:P30530)

Seeded From UniProt

complete

See also

References

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