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PMID:7789282

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Citation

Conlon, RA, Reaume, AG and Rossant, J (1995) Notch1 is required for the coordinate segmentation of somites. Development 121:1533-45

Abstract

Members of the Notch family of transmembrane receptors mediate a number of developmental decisions in invertebrates. In order to study Notch function in a vertebrate organism, we have mutated the Notch1 gene of the mouse. Notch1 gene function is required for embryonic survival in the second half of gestation. In the first half of gestation, we have found no effect of the mutation on the normal programs of neurogenesis, myogenesis or apoptosis. We conclude that Notch1 function is not essential for these processes, at least in early postimplantation development. However, we have found that somitogenesis is delayed and disorganized in Notch1 mutant embryos. We propose that Notch1 normally coordinates the process of somitogenesis, and we provide a model of how this might occur.

Links

PubMed

Keywords

Animals; Apoptosis/physiology; Embryonic Induction/physiology; Gene Expression; Genotype; Immunohistochemistry; In Situ Hybridization; Membrane Proteins/genetics; Membrane Proteins/physiology; Mesoderm/physiology; Mice; Mice, Transgenic; Models, Genetic; Molecular Sequence Data; Morphogenesis/physiology; Mutagenesis, Site-Directed; Phenotype; Receptors, Notch

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:NOTC1

acts_upstream_of_or_within

GO:0021915: neural tube development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857230

P

Seeded From UniProt

complete

MOUSE:NOTC1

acts_upstream_of_or_within

GO:0001701: in utero embryonic development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857230

P

Seeded From UniProt

complete

MOUSE:NOTC1

acts_upstream_of_or_within

GO:0007368: determination of left/right symmetry

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857230

P

Seeded From UniProt

complete

MOUSE:NOTC1

acts_upstream_of_or_within

GO:0014807: regulation of somitogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857230

P

Seeded From UniProt

complete

MOUSE:NOTC1

acts_upstream_of_or_within

GO:0060548: negative regulation of cell death

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857230

P

Seeded From UniProt

complete


See also

References

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