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PMID:7732381

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Citation

Fernandez-Salguero, P, Pineau, T, Hilbert, DM, McPhail, T, Lee, SS, Kimura, S, Nebert, DW, Rudikoff, S, Ward, JM and Gonzalez, FJ (1995) Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor. Science 268:722-6

Abstract

The aryl hydrocarbon (Ah) receptor (AHR) mediates many carcinogenic and teratogenic effects of environmentally toxic chemicals such as dioxin. An AHR-deficient (Ahr-/-) mouse line was constructed by homologous recombination in embryonic stem cells. Almost half of the mice died shortly after birth, whereas survivors reached maturity and were fertile. The Ahr-/- mice showed decreased accumulation of lymphocytes in the spleen and lymph nodes, but not in the thymus. The livers of Ahr-/- mice were reduced in size by 50 percent and showed bile duct fibrosis Ahr-/- mice were also nonresponsive with regard to dioxin-mediated induction of genes encoding enzymes that catalyze the metabolism of foreign compounds. Thus, the AHR plays an important role in the development of the liver and the immune system.

Links

PubMed

Keywords

Animals; Female; Gene Expression Regulation/physiology; Immunity/physiology; Liver/physiology; Liver Cirrhosis, Experimental/genetics; Liver Cirrhosis, Experimental/pathology; Lymphoid Tissue/pathology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Aryl Hydrocarbon/genetics; Receptors, Aryl Hydrocarbon/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:AHR

involved_in

GO:0002376: immune system process

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:AHR

involved_in

GO:0002260: lymphocyte homeostasis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:AHR

involved_in

GO:0001889: liver development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:AHR

involved_in

GO:0001782: B cell homeostasis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:AHR

involved_in

GO:0048536: spleen development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:AHR

involved_in

GO:0043029: T cell homeostasis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:AHR

involved_in

GO:0040010: positive regulation of growth rate

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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