GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:7553861

From GONUTS
Jump to: navigation, search
Citation

Herman, MA, Vassilieva, LL, Horvitz, HR, Shaw, JE and Herman, RK (1995) The C. elegans gene lin-44, which controls the polarity of certain asymmetric cell divisions, encodes a Wnt protein and acts cell nonautonomously. Cell 83:101-10

Abstract

Mutations in the C. elegans gene lin-44 lead to reversals in the polarity of certain asymmetric cell divisions. We have discovered that lin-44 is a member of the Wnt family of genes, which encode secretory glycoproteins implicated in intercellular signaling. Both in situ hybridization experiments using lin-44 transcripts and experiments using reporter constructs designed to mimic patterns of lin-44 expression indicate that lin-44 is expressed in hypodermal cells at the tip of the tail and posterior to the cells with polarities affected by lin-44 mutations. Our mosaic analysis indicates that lin-44 acts cell nonautonomously. We propose that LIN-44 protein is secreted by tail hypodermal cells and affects the polarity of asymmetric cell divisions that occur more anteriorly in the tail.

Links

PubMed

Keywords

Amino Acid Sequence; Animals; Base Sequence; Caenorhabditis elegans/cytology; Caenorhabditis elegans/genetics; Caenorhabditis elegans Proteins; Cell Division; Cell Lineage; Cell Polarity/genetics; Chromosomes, Artificial, Yeast; Consensus Sequence; DNA, Complementary/genetics; Disorders of Sex Development; Drosophila Proteins; Drosophila melanogaster/genetics; Gene Expression Regulation; Genes, Reporter; Glycoproteins/chemistry; Glycoproteins/classification; Glycoproteins/genetics; Glycoproteins/physiology; Helminth Proteins/physiology; In Situ Hybridization; Mice; Molecular Sequence Data; Mosaicism; Multigene Family; Phenotype; Proto-Oncogene Proteins/chemistry; Proto-Oncogene Proteins/genetics; Recombinant Fusion Proteins/biosynthesis; Recombinant Fusion Proteins/genetics; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Tail; Wnt1 Protein

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CAEEL:WNT1

involved_in

GO:0016055: Wnt signaling pathway

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P09544

P

Seeded From UniProt

complete

CAEEL:WNT1

enables

GO:0005109: frizzled binding

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P09544

F

Seeded From UniProt

complete

CAEEL:WNT2

involved_in

GO:0016055: Wnt signaling pathway

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P09544

P

Seeded From UniProt

complete

CAEEL:WNT2

enables

GO:0005109: frizzled binding

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P09544

F

Seeded From UniProt

complete

CAEEL:LIN44

involved_in

GO:0016055: Wnt signaling pathway

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P24383

P

Seeded From UniProt

complete

CAEEL:LIN44

enables

GO:0005109: frizzled binding

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P24383

F

Seeded From UniProt

complete

CAEEL:LIN44

enables

GO:0048018: receptor ligand activity

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:O00755

F

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.