GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:7520869

From GONUTS
Jump to: navigation, search
Citation

Hutter, P and Karch, F (1994) Molecular analysis of a candidate gene for the reproductive isolation between sibling species of Drosophila. Experientia 50:749-62

Abstract

The X-linked gene Hmr in Drosophila melanogaster, when mutated, rescues otherwise inviable interspecific hybrids from crosses between D. melanogaster and any of its three most closely related species D. simulans, D. mauritiana and D. sechellia. DNA from the site of a breakpoint at the putative locus of the gene has been cloned, and results of transcription and sequence analyses are presented. Three distinct mRNAs are transcribed from this locus, two of which are abundantly expressed throughout life. A third transcript, which is larger but rarer, appears to be disrupted by at least one of the two known mutations of Hmr. The gene encodes a mitochondrial ADP/ATP translocator protein, which plays an essential role in maintaining metabolic energy. Analysis of several cDNAs suggested that the rescue of hybrids may be dependent on mutations in the variable 3' end region of this gene, affecting the level and/or the stability of the largest messenger RNA.

Links

PubMed

Keywords

Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Blotting, Southern; Chromosome Walking; Crosses, Genetic; DNA/analysis; Drosophila/genetics; Drosophila melanogaster/genetics; Female; Genes, Insect; Genomic Library; Male; Mitochondrial ADP, ATP Translocases/genetics; Molecular Sequence Data; Phenotype; RNA/analysis; Reproduction/genetics; Restriction Mapping; Species Specificity; X Chromosome

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:ADT

involved_in

GO:0006839: mitochondrial transport

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:ADT

located_in

GO:0005743: mitochondrial inner membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.