GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:4148765

From GONUTS
Jump to: navigation, search
Citation

Thèze, J, Margarita, D, Cohen, GN, Borne, F and Patte, JC (1974) Mapping of the structural genes of the three aspartokinases and of the two homoserine dehydrogenases of Escherichia coli K-12. J. Bacteriol. 117:133-43

Abstract

Mutants requiring threonine plus methionine (or homoserine), or threonine plus methionine plus diaminopimelate (or homoserine plus diaminopimelate) have been isolated from strains possessing only one of the three isofunctional aspartokinases. They have been classified in several groups according to their enzymatic defects. Their mapping is described. Several regions of the chromosome are concerned: thrA (aspartokinase I-homoserine dehydrogenase I) is mapped in the same region as thrB and thrC (0 min). lysC (aspartokinase III) is mapped at 80 min, far from the other genes coding for diaminopimelate synthesis. metLM (aspartokinase II-homoserine dehydrogenase II) lies at 78 min closely linked to metB, metJ, and metF.

Links

PubMed PMC246534

Keywords

Alcohol Oxidoreductases/biosynthesis; Alcohol Oxidoreductases/metabolism; Aspartate-Semialdehyde Dehydrogenase/metabolism; Chromosome Mapping; Crosses, Genetic; Escherichia coli/enzymology; Escherichia coli/metabolism; Genes; Homoserine/metabolism; Isoenzymes/biosynthesis; L-Lactate Dehydrogenase/metabolism; Methionine/metabolism; Mutagens; Mutation; Nitrosoguanidines; Phosphotransferases/biosynthesis; Phosphotransferases/metabolism; Pyruvate Kinase/metabolism; Threonine/metabolism; Transduction, Genetic

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

ECOLI:KHSE

acts_upstream_of_or_within

GO:0009088: threonine biosynthetic process

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ECOLI:THRC

acts_upstream_of_or_within

GO:0009088: threonine biosynthetic process

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ECOLI:THRC

involved_in

GO:0009088: threonine biosynthetic process

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.