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PMID:2992770

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Citation

Garry, RF, Shackleford, GM, Berry, LJ and Bose, HR Jr (1985) Inhibition of hepatic phosphoenolpyruvate carboxykinase by avian reticuloendotheliosis viruses. Cancer Res. 45:5020-6

Abstract

Severe weight loss is associated with many malignant diseases of humans and animals. Avian reticuloendotheliosis viruses (RE viruses) induce runting in experimentally infected chickens. Chickens infected with a replication-competent RE virus, reticuloendotheliosis-associated virus, weighed 30-50% less than control birds at the time of death. Chickens infected with reticuloendotheliosis virus, a replication-defective acute leukemia virus, weighed 30% less than the controls. The runting induced by RE viruses does not occur because of reduced food intake. Activities of phosphoenolpyruvate carboxykinase, a key gluconeogenic enzyme in the liver, were reduced approximately 40 and 50%, respectively, by infection with reticuloendotheliosis-associated virus and reticuloendotheliosis virus. RE virus infection, however, did not affect the hepatic pyruvate carboxylase activity, indicating that inhibition of phosphoenolpyruvate carboxykinase is not due to a general inhibition of all liver enzymes. Birds given injections of UV-inactivated RE viruses or reticuloendotheliosis virus-transformed, non-virus-producing tumor cells also exhibited a reduction in phosphoenolpyruvate carboxykinase activity.

Links

PubMed

Keywords

Animals; Chick Embryo; Eating; Helper Viruses; Liver/enzymology; Phosphoenolpyruvate Carboxykinase (GTP)/metabolism; Reticuloendotheliosis virus/radiation effects; Tumor Virus Infections/enzymology; Virus Replication

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CHICK:PCKGC

involved_in

GO:0045912: negative regulation of carbohydrate metabolic process

ECO:0000316: genetic interaction evidence used in manual assertion

UniProtKB:Q5G5J9

P

Seeded From UniProt

complete

CHICK:PCKGC

involved_in

GO:0045912: negative regulation of carbohydrate metabolic process

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

CHICK:PCKGC

involved_in

GO:0048589: developmental growth

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

CHICK:PCKGC

involved_in

GO:0045913: positive regulation of carbohydrate metabolic process

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

Notes

See also

References

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