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PMID:28438015
| Citation |
Jang, SY, Heo, J, Park, MR, Song, MH, Kim, JN, Jo, SH, Jeong, DY, Lee, HK, Kim, Y and Oh, S' (2017) Genome Characteristics of Lactobacillus fermentum strain JDFM216 for Application as Probiotic Bacteria. J. Microbiol. Biotechnol. ' |
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| Abstract |
Lactobacillus fermentum strain JDFM216, isolated from a Korean infant feces, possesses an enhancement of longevity and immune response on Caenorhabditis elegans host. To explore the molecular characteristics of strain JDFM216, we performed a whole-genome sequencing using PacBio system. The single circular DNA chromosome of 2,076,427 bp was completely assembled and 2,623 encoding sequences were predicted. Phylogenetically featured five genes possibly related to longevity and immune response of host were identified in L. fermentum strain JDFM216. These genes encode UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7), ErfK/YbiS/YcfS/YnhG family protein, site-specific recombinase XerD, homocysteine S-methyltransferase (EC 2.1.1.10), and aspartate-ammonia ligase (EC 6.3.1.1), which are peptidoglycan synthesis and amino acid metabolism in the gut environment. Our findings suggest that the genetic backgrounds of L. fermentum strain JDFM216 and its potential candidate genes for host longevity and immune response provide new insight for applying on food industry as newly isolated functional probiotics. |
| Links |
PubMed Online version:10.4014/jmb.1703.03013 |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
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