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PMID:28344082

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Citation

Legnini, I, Di Timoteo, G, Rossi, F, Morlando, M, Briganti, F, Sthandier, O, Fatica, A, Santini, T, Andronache, A, Wade, M, Laneve, P, Rajewsky, N and Bozzoni, I (2017) Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Mol. Cell 66:22-37.e9

Abstract

Circular RNAs (circRNAs) constitute a family of transcripts with unique structures and still largely unknown functions. Their biogenesis, which proceeds via a back-splicing reaction, is fairly well characterized, whereas their role in the modulation of physiologically relevant processes is still unclear. Here we performed expression profiling of circRNAs during in vitro differentiation of murine and human myoblasts, and we identified conserved species regulated in myogenesis and altered in Duchenne muscular dystrophy. A high-content functional genomic screen allowed the study of their functional role in muscle differentiation. One of them, circ-ZNF609, resulted in specifically controlling myoblast proliferation. Circ-ZNF609 contains an open reading frame spanning from the start codon, in common with the linear transcript, and terminating at an in-frame STOP codon, created upon circularization. Circ-ZNF609 is associated with heavy polysomes, and it is translated into a protein in a splicing-dependent and cap-independent manner, providing an example of a protein-coding circRNA in eukaryotes.

Links

PubMed PMC5387670 Online version:10.1016/j.molcel.2017.02.017

Keywords


Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:ZN609

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:ZN609

involved_in

GO:2000291: regulation of myoblast proliferation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:ZN609

involved_in

GO:2000291: regulation of myoblast proliferation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:MYH7

GO:0003009: skeletal muscle contraction

ECO:0000315:

P

Effects RNA splicing in myoblast formation, causes dysfunction in muscle contraction. More commonly associated with Duchenne Muscular Dystrophy.

complete
CACAO 12762

Notes

See also

References

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