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PMID:28034798

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Citation

Schultzhaus, Z, Zheng, W, Wang, Z, Mouriño-Pérez, R and Shaw, B (2017) Phospholipid flippases DnfA and DnfB exhibit differential dynamics within the A. nidulans Spitzenkörper. Fungal Genet. Biol. 99:26-28

Abstract

The Spitzenkörper is a structure at the apex of growing cells in many filamentous fungi. Ultrastructural studies indicate that the Spitzenkörper is an organized mass of secretory vesicles, with different types of vesicles present in outer and inner layers. Here, we used live-cell imaging to demonstrate that the phospholipid flippases DnfA and DnfB, which preferentially localize to the outer and inner layers, respectively, exhibit different dynamics in the Spitzenkörper of Aspergillus nidulans. Additionally, deletion of dnfA partially destabilized the Spitzenkörper, while the depletion of cdc50, an essential β-subunit of most flippases, had dramatic effects on hyphal tip organization and morphology.

Links

PubMed Online version:10.1016/j.fgb.2016.12.007

Keywords


Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

EMENI:Q5ASQ8

GO:0031521: spitzenkorper

ECO:0000314:

C

A. nidulans dnfA=AN8672 A. nidulans DnfA and DnfB preferentially localize to different regions of the SPK and the PM ( Fig. 1A), with DnfA concentrated on the outside of the SPK and DnfB within the SPK core.

complete
CACAO 12235

EMENI:Q5ASQ8

GO:0005886: plasma membrane

ECO:0000314:

C

A. nidulans. (DnfA=AN8672) Fig. 1A Spitzenkörper protein dynamics in Aspergillus nidulans. (A)Thin Arrows indicate plasma membrane localization of DnfA

complete
CACAO 12236

EMENI:Q5B018

GO:0031521: spitzenkorper

ECO:0000314:

C

A. nidulans (DfnB=AN61120 Fig. 1. Spitzenkörper protein dynamics in Aspergillus nidulans. (A) Localization of flippases DnfA and DnfB within the Spitzenkörper of A. nidulans. A. nidulans DnfA and DnfB preferentially localize to different regions of the SPK and the PM ( Fig. 1A), with DnfA concentrated on the outside of the SPK and DnfB within the SPK core.

complete
CACAO 12237

Notes

See also

References

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