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PMID:28012171

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Citation

Ito, N, Sakai, A, Miyake, N, Maruyama, M, Iwasaki, H, Miyake, K, Okada, T, Sakamoto, A and Suzuki, H (2017) miR-15b mediates oxaliplatin-induced chronic neuropathic pain through BACE1 down-regulation. Br. J. Pharmacol. 174:386-395

Abstract

Although oxaliplatin is an effective anti-cancer platinum compound, it can cause painful chronic neuropathy, and its molecular mechanisms are poorly understood. MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression in a sequence-specific manner. Although miRNAs have been increasingly recognized as important modulators in a variety of pain conditions, their involvement in chemotherapy-induced neuropathic pain is unknown.

Links

PubMed PMC5301044 Online version:10.1111/bph.13698

Keywords

Amyloid Precursor Protein Secretases/genetics; Animals; Antineoplastic Agents/toxicity; Aspartic Acid Endopeptidases/genetics; Down-Regulation/genetics; Ganglia, Spinal/metabolism; Injections, Intraperitoneal; Male; MicroRNAs/genetics; Neuralgia/chemically induced; Neuralgia/genetics; Neurons/metabolism; Organoplatinum Compounds/toxicity; Oxaliplatin; Rats; Rats, Sprague-Dawley

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:BACE1

involved_in

GO:0050966: detection of mechanical stimulus involved in sensory perception of pain

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

Notes

See also

References

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