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PMID:27542896
| Citation |
Randazzo, P, Aubert-Frambourg, A, Guillot, A and Auger, S (2016) The MarR-like protein PchR (YvmB) regulates expression of genes involved in pulcherriminic acid biosynthesis and in the initiation of sporulation in Bacillus subtilis. BMC Microbiol. 16:190 |
|---|---|
| Abstract |
Cyclodipeptides and their derivatives constitute a large class of peptide natural products with noteworthy biological activities. In some yeasts and bacterial species, pulcherriminic acid derived from cyclo-L-leucyl-L-leucyl is excreted and chelates free ferric ions to form the pulcherrimin. In Bacillus subtilis, the enzymes YvmC and CypX are known to be involved in pulcherriminic acid biosynthesis. However, the mechanisms controlling the transcription of the yvmC-cypX operon are still unknown. |
| Links |
PubMed PMC4992311 Online version:10.1186/s12866-016-0807-3 |
| Keywords |
Bacillus subtilis/enzymology; Bacillus subtilis/genetics; Bacillus subtilis/metabolism; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Binding Sites; Gene Deletion; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Gene Fusion; Gene Regulatory Networks; Iron/metabolism; Metabolic Networks and Pathways; Promoter Regions, Genetic; Pyrazines/metabolism; Transcription Factors/genetics; Transcription Factors/metabolism |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0045892: negative regulation of transcription, DNA-templated |
ECO:0000315: |
P |
Figure 3C shows that “ CcpA acts as negative regulator of yvmB expression.” Organism: Bacillus subtilis |
complete | ||||
| GO:0045892: negative regulation of transcription, DNA-templated |
ECO:0000315: |
P |
Figure 9A and 9B shows that YvmB negatively regulates yvnB expression. Organism: Bacillus subtilis. “YvmB was renamed as PchR controlling the pulcherriminic acid biosynthetic pathway of B. subtilis.” |
complete | ||||
| GO:0045893: positive regulation of transcription, DNA-templated |
ECO:0000315: |
P |
Figures 9C and 9D shows that “YvmB positively regulates yisI expression.” Organism: Bacillus subtilis . “YvmB was renamed as PchR controlling the pulcherriminic acid biosynthetic pathway of B. subtilis.” |
complete | ||||
Notes
See also
References
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