GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:24688219

From GONUTS
Jump to: navigation, search
Citation

Nakahashi, O, Yamamoto, H, Tanaka, S, Kozai, M, Takei, Y, Masuda, M, Kaneko, I, Taketani, Y, Iwano, M, Miyamoto, K and Takeda, E (2014) Short-term dietary phosphate restriction up-regulates ileal fibroblast growth factor 15 gene expression in mice. J Clin Biochem Nutr 54:102-8

Abstract

Members of the fibroblast growth factor (FGF) 19 subfamily, including FGF23, FGF15/19, and FGF21, have a role as endocrine factors which influence the metabolism of inorganic phosphate (Pi) and vitamin D, bile acid, and energy. It has been reported that dietary Pi regulates circulating FGF23. In this study, the short-term effects of dietary Pi restriction on the expression of FGF19 subfamily members in mice were analyzed. An initial analysis confirmed plasma FGF23 levels positively correlated with the amount of dietary Pi. On the other hand, ileal Fgf15 gene expression, but not hepatic Fgf21 gene expression, was up-regulated by dietary Pi restriction. In addition, we observed the increase of plasma 1,25-dihydroxyvitamin D [1,25(OH)2D] levels by dietary Pi restriction, and the up-regulation of ileal Fgf15 mRNA expression by 1,25(OH)2D3 and vitamin D receptor (VDR). Importantly, dietary Pi restriction-induced Fgf15 gene expression was prevented in VDR-knockout mice. Furthermore, diurnal variations of plasma triglyceride concentrations and hepatic mRNA expression of the bile acid synthesis enzyme Cyp7a1 as one of Fgf15 negative target genes was influenced by dietary Pi restriction. These results suggest that dietary Pi restriction up-regulates ileal Fgf15 gene expression through 1,25(OH)2D3 and VDR, and may affect hepatic bile acid homeostasis.

Links

PubMed PMC3947966 Online version:10.3164/jcbn.13-109

Keywords


Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:FGF15

GO:0060557: positive regulation of vitamin D biosynthetic process

ECO:0000314:

P

According to figure 1C, Fgf15 mRNA expression in the ileum was significantly increased in the mice fed the 0.1% Pi diet compared with groups fed the 0.6% or 1.2% Pi diet. Therefore, dietary Pi restriction up-regulates ileal Fgf15 gene expression.

complete
CACAO 9815

See also

References

See Help:References for how to manage references in GONUTS.