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PMID:24688219
Citation |
Nakahashi, O, Yamamoto, H, Tanaka, S, Kozai, M, Takei, Y, Masuda, M, Kaneko, I, Taketani, Y, Iwano, M, Miyamoto, K and Takeda, E (2014) Short-term dietary phosphate restriction up-regulates ileal fibroblast growth factor 15 gene expression in mice. J Clin Biochem Nutr 54:102-8 |
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Abstract |
Members of the fibroblast growth factor (FGF) 19 subfamily, including FGF23, FGF15/19, and FGF21, have a role as endocrine factors which influence the metabolism of inorganic phosphate (Pi) and vitamin D, bile acid, and energy. It has been reported that dietary Pi regulates circulating FGF23. In this study, the short-term effects of dietary Pi restriction on the expression of FGF19 subfamily members in mice were analyzed. An initial analysis confirmed plasma FGF23 levels positively correlated with the amount of dietary Pi. On the other hand, ileal Fgf15 gene expression, but not hepatic Fgf21 gene expression, was up-regulated by dietary Pi restriction. In addition, we observed the increase of plasma 1,25-dihydroxyvitamin D [1,25(OH)2D] levels by dietary Pi restriction, and the up-regulation of ileal Fgf15 mRNA expression by 1,25(OH)2D3 and vitamin D receptor (VDR). Importantly, dietary Pi restriction-induced Fgf15 gene expression was prevented in VDR-knockout mice. Furthermore, diurnal variations of plasma triglyceride concentrations and hepatic mRNA expression of the bile acid synthesis enzyme Cyp7a1 as one of Fgf15 negative target genes was influenced by dietary Pi restriction. These results suggest that dietary Pi restriction up-regulates ileal Fgf15 gene expression through 1,25(OH)2D3 and VDR, and may affect hepatic bile acid homeostasis. |
Links |
PubMed PMC3947966 Online version:10.3164/jcbn.13-109 |
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Significance
Annotations
Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
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GO:0060557: positive regulation of vitamin D biosynthetic process |
ECO:0000314: |
P |
According to figure 1C, Fgf15 mRNA expression in the ileum was significantly increased in the mice fed the 0.1% Pi diet compared with groups fed the 0.6% or 1.2% Pi diet. Therefore, dietary Pi restriction up-regulates ileal Fgf15 gene expression. |
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