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PMID:24558379
| Citation |
Kiene, M, Rethi, B, Jansson, M, Dillon, S, Lee, E, Lantto, R, Wilson, C, Pöhlmann, S and Chiodi, F (2014) Toll-Like Receptor 3 Signalling Up-Regulates Expression of the HIV Co-Receptor G-Protein Coupled Receptor 15 on Human CD4(+) T Cells. PLoS ONE 9:e88195 |
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| Abstract |
Many HIV-2 and SIV isolates, as well as some HIV-1 strains, can use the orphan 7-transmembrane receptor GPR15 as co-receptor for efficient entry into host cells. GPR15 is expressed on central memory and effector memory CD4(+) T cells in healthy individuals and a subset of these cells is susceptible to HIV-1 and SIV infection. However, it has not been determined whether GPR15 expression is altered in the context of HIV-1 infection. |
| Links |
PubMed PMC3928197 Online version:10.1371/journal.pone.0088195 |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0010467: gene expression |
ECO:0000314: |
P |
Uninfected or infected cells expressing GPR15, Fig 2 |
complete | ||||
See also
References
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