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PMID:24210121

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Citation

Stewart, CR, Deery, WJ, Egan, ES, Myles, B and Petti, AA (2013) The product of SPO1 gene 56 inhibits host cell division during infection of Bacillus subtilis by bacteriophage SPO1. Virology 447:249-53

Abstract

Although cells of Bacillus subtilis continue to grow after being infected by bacteriophage SPO1, they do not undergo cell division. The product of SPO1 gene 56 is necessary and sufficient for this inhibition of cell division. GP56 inhibits cell division when expressed in uninfected B. subtilis, without preventing cell growth, DNA synthesis or chromosome segregation, ultimately causing filamentation and loss of viability. During infection, a gene 56 mutation prevents the inhibition of cell division that occurs in wild-type infection. Under the laboratory conditions used, the gene 56 mutation did not affect burst size, latent period, or other components of the host-takeover process.

Links

PubMed Online version:10.1016/j.virol.2013.09.005

Keywords

Bacillus Phages/growth & development; Bacillus subtilis/cytology; Bacillus subtilis/growth & development; Bacillus subtilis/physiology; Bacillus subtilis/virology; Cell Division/drug effects; Chromosome Segregation/drug effects; DNA Replication/drug effects; Host-Parasite Interactions; Microbial Viability/drug effects; Viral Proteins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

BPSP1:B6V2W3

GO:0044865: negative regulation by virus of host cell division

ECO:0000315:

P

In Fig. 1, in trans expression of gp56 results in normal increase in cell mass but not in CFU; in Fig. 2, in trans expression of gp56 results in cell filamentation.

complete

Notes

See also

References

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