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PMID:24192653

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Citation

Bhandari, P, Song, M, Chen, Y, Burelle, Y and Dorn, GW 2nd (2014) Mitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusin. Circ. Res. 114:257-65

Abstract

Dysfunctional Parkin-mediated mitophagic culling of senescent or damaged mitochondria is a major pathological process underlying Parkinson disease and a potential genetic mechanism of cardiomyopathy. Despite epidemiological associations between Parkinson disease and heart failure, the role of Parkin and mitophagic quality control in maintaining normal cardiac homeostasis is poorly understood.

Links

PubMed PMC4392818 Online version:10.1161/CIRCRESAHA.114.302734

Keywords

Animals; Calcium Signaling; Cardiomyopathy, Dilated/enzymology; Cardiomyopathy, Dilated/genetics; Cardiomyopathy, Dilated/pathology; Cardiomyopathy, Dilated/prevention & control; Drosophila Proteins/deficiency; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila melanogaster/enzymology; Drosophila melanogaster/genetics; Gene Expression Profiling; Genotype; Heart Failure/enzymology; Heart Failure/genetics; Heart Failure/pathology; Membrane Proteins/metabolism; Mitochondria, Heart/enzymology; Mitochondria, Heart/pathology; Mitochondrial Degradation; Mitochondrial Dynamics; Mutation; Myocytes, Cardiac/enzymology; Myocytes, Cardiac/pathology; Phenotype; RNA Interference; Reactive Oxygen Species/metabolism; Signal Transduction; Time Factors; Ubiquitin-Protein Ligases/deficiency; Ubiquitin-Protein Ligases/genetics

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:SODC

involved_in

GO:1903146: regulation of autophagy of mitochondrion

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0041100

P

Seeded From UniProt

complete

DROME:SODM

involved_in

GO:1903146: regulation of autophagy of mitochondrion

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0041100

P

Seeded From UniProt

complete

DROME:PRKN

involved_in

GO:0000422: autophagy of mitochondrion

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VUM2

involved_in

GO:1903146: regulation of autophagy of mitochondrion

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0041100

P

Seeded From UniProt

complete

DROME:Q7KTX7

involved_in

GO:0000422: autophagy of mitochondrion

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

Notes

See also

References

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