PMID:24090070

Citation	Cooper, CA, Mulder, DT, Allison, SE, Pilar, AV and Coombes, BK (2013) The SseC translocon component in Salmonella enterica serovar Typhimurium is chaperoned by SscA. BMC Microbiol. 13:221
Abstract	Salmonella enterica is a causative agent of foodborne gastroenteritis and the systemic disease known as typhoid fever. This bacterium uses two type three secretion systems (T3SSs) to translocate protein effectors into host cells to manipulate cellular function. Salmonella pathogenicity island (SPI)-2 encodes a T3SS required for intracellular survival of the pathogen. Genes in SPI-2 include apparatus components, secreted effectors and chaperones that bind to secreted cargo to coordinate their release from the bacterial cell. Although the effector repertoire secreted by the SPI-2 T3SS is large, only three virulence-associated chaperones have been characterized.
Links	PubMed Online version:10.1186/1471-2180-13-221
Keywords
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
SALTS:A0A0H3NB70	enables	GO:0005515: protein binding	ECO:0000353: physical interaction evidence used in manual assertion	UniProtKB:A0A0H3NG86	F		Seeded From UniProt	complete
SALTS:A0A0H3NG86	enables	GO:0005515: protein binding	ECO:0000353: physical interaction evidence used in manual assertion	UniProtKB:A0A0H3NB70	F		Seeded From UniProt	complete
SALTY:H9L426	enables	GO:0005515: protein binding	ECO:0000353: physical interaction evidence used in manual assertion	UniProtKB:O84947	F		Seeded From UniProt	complete
SALTY:H9L426	involved_in	GO:0050714: positive regulation of protein secretion	ECO:0000315: mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:O84947)	Seeded From UniProt	complete
SALTY:SSEC	part_of	GO:0005576: extracellular region	ECO:0000314: direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
SALTY:SSEC	part_of	GO:0005737: cytoplasm	ECO:0000314: direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
SALTY:SSEC	enables	GO:0051087: chaperone binding	ECO:0000353: physical interaction evidence used in manual assertion	UniProtKB:H9L426	F		Seeded From UniProt	complete
SALTM:O84946	involved_in	GO:0072321: chaperone-mediated protein transport	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
SALTM:O84946		GO:0072321: chaperone-mediated protein transport	ECO:0000315:		P		Figure 3 western blot of WT SscA and mutant SscA demonstrate that secretion of SseC is mediated by SscA.	complete CACAO 8974

References

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