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PMID:24090070

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Citation

Cooper, CA, Mulder, DT, Allison, SE, Pilar, AV and Coombes, BK (2013) The SseC translocon component in Salmonella enterica serovar Typhimurium is chaperoned by SscA. BMC Microbiol. 13:221

Abstract

Salmonella enterica is a causative agent of foodborne gastroenteritis and the systemic disease known as typhoid fever. This bacterium uses two type three secretion systems (T3SSs) to translocate protein effectors into host cells to manipulate cellular function. Salmonella pathogenicity island (SPI)-2 encodes a T3SS required for intracellular survival of the pathogen. Genes in SPI-2 include apparatus components, secreted effectors and chaperones that bind to secreted cargo to coordinate their release from the bacterial cell. Although the effector repertoire secreted by the SPI-2 T3SS is large, only three virulence-associated chaperones have been characterized.

Links

PubMed Online version:10.1186/1471-2180-13-221

Keywords


Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

SALTS:A0A0H3NB70

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:A0A0H3NG86

F

Seeded From UniProt

complete

SALTS:A0A0H3NG86

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:A0A0H3NB70

F

Seeded From UniProt

complete

SALTY:H9L426

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:O84947

F

Seeded From UniProt

complete

SALTY:H9L426

involved_in

GO:0050714: positive regulation of protein secretion

ECO:0000315: mutant phenotype evidence used in manual assertion

P

  • has_input:(UniProtKB:O84947)

Seeded From UniProt

complete

SALTY:SSEC

part_of

GO:0005576: extracellular region

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

SALTY:SSEC

part_of

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

SALTY:SSEC

enables

GO:0051087: chaperone binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:H9L426

F

Seeded From UniProt

complete

SALTM:O84946

involved_in

GO:0072321: chaperone-mediated protein transport

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

SALTM:O84946

GO:0072321: chaperone-mediated protein transport

ECO:0000315:

P

Figure 3 western blot of WT SscA and mutant SscA demonstrate that secretion of SseC is mediated by SscA.

complete
CACAO 8974

See also

References

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