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PMID:23900597

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Citation

Liu, Q, Gibson, MP, Sun, H and Qin, C (2013) Dentin sialophosphoprotein (DSPP) plays an essential role in the postnatal development and maintenance of mouse mandibular condylar cartilage. J. Histochem. Cytochem. 61:749-58

Abstract

Recently, dentin sialophosphoprotein (DSPP) was found to be expressed in the mandibular condylar cartilage (MCC), but the possible roles of this molecule in the formation, growth, and maintenance of the cartilage are largely unclear. To analyze such roles, we examined Dspp null mice compared with wild-type mice to assess the consequences of Dspp deletion on the morphology and structure of the MCC. Our data showed that DSPP is expressed in the prechondroblastic, chondroblastic, hypertrophic layers of the MCC. Dspp null mice exhibited decreases in the amount of MCC, with reduced formation of articular and prechondroblastic layers in which progenitor cell proliferation levels were distinctly affected. The expression of extracellular matrix molecules, including biglycan and collagen II, IX, and X, was remarkably altered. The findings in this study indicate that continuous DSPP action is required for the growth and/or maintenance of the MCC.

Links

PubMed PMC3788629 Online version:10.1369/0022155413502056

Keywords

Animals; Biglycan/metabolism; Cartilage/cytology; Cartilage/growth & development; Cartilage/metabolism; Cell Proliferation; Collagen/metabolism; Extracellular Matrix Proteins/deficiency; Extracellular Matrix Proteins/genetics; Extracellular Matrix Proteins/metabolism; Gene Deletion; Gene Expression Regulation; Mandibular Condyle/growth & development; Mandibular Condyle/metabolism; Mice; Phosphoproteins/deficiency; Phosphoproteins/genetics; Phosphoproteins/metabolism; Sialoglycoproteins/deficiency; Sialoglycoproteins/genetics; Sialoglycoproteins/metabolism; Stem Cells/cytology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:CO2A1

located_in

GO:0031012: extracellular matrix

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:PGS1

located_in

GO:0031012: extracellular matrix

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:DSPP

acts_upstream_of_or_within

GO:0061978: mandibular condyle articular cartilage development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2653208

P

Seeded From UniProt

complete

MOUSE:DSPP

acts_upstream_of_or_within

GO:1901148: gene expression involved in extracellular matrix organization

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2653208

P

  • occurs_in:(EMAPA:17376)

Seeded From UniProt

complete

MOUSE:DSPP

acts_upstream_of_or_within

GO:1902732: positive regulation of chondrocyte proliferation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2653208

P

Seeded From UniProt

complete

MOUSE:PGS1

part_of

GO:0031012: extracellular matrix

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

Notes

See also

References

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