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PMID:23873704

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Citation

Li, J, Li, J, Liu, X, Qin, S, Guan, Y, Liu, Y, Cheng, Y, Chen, X, Li, W, Wang, S, Xiong, M, Kuzhikandathil, EV, Ye, JH and Zhang, C (2013) MicroRNA expression profile and functional analysis reveal that miR-382 is a critical novel gene of alcohol addiction. EMBO Mol Med 5:1402-14

Abstract

Alcohol addiction is a major social and health concern. Here, we determined the expression profile of microRNAs (miRNAs) in the nucleus accumbens (NAc) of rats treated with alcohol. The results suggest that multiple miRNAs were aberrantly expressed in rat NAc after alcohol injection. Among them, miR-382 was down-regulated in alcohol-treated rats. In both cultured neuronal cells in vitro and in the NAc in vivo, we identified that the dopamine receptor D1 (Drd1) is a direct target gene of miR-382. Via this target gene, miR-382 strongly modulated the expression of DeltaFosB. Moreover, overexpression of miR-382 significantly attenuated alcohol-induced up-regulation of DRD1 and DeltaFosB, decreased voluntary intake of and preference for alcohol and inhibited the DRD1-induced action potential responses. The results indicated that miRNAs are involved in and may represent novel therapeutic targets for alcoholism.

Links

PubMed PMC3799494 Online version:10.1002/emmm.201201900

Keywords

Alcoholism/genetics; Animals; Ethanol/metabolism; Gene Expression Profiling; Gene Expression Regulation; MicroRNAs/genetics; MicroRNAs/metabolism; Nucleus Accumbens/drug effects; Nucleus Accumbens/physiopathology; Proto-Oncogene Proteins c-fos/biosynthesis; Rats; Receptors, Dopamine D1/biosynthesis

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:DRD1

involved_in

GO:0045471: response to ethanol

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

Notes

See also

References

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