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PMID:23510478

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Citation

Bai, C, Hou, L, Zhang, M, Wang, L, Guan, W and Ma, Y (2013) Identification and biological characterization of chicken embryonic cardiac progenitor cells. Cell Prolif. 46:232-42

Abstract

Many kinds of cardiac progenitor cell populations have been identified, including c-kit(+) , Nkx2.5(+) s and GATA4(+) cells. However, these progenitors have limited ability to differentiate into different cardiac cell types. Recently, a new kind of cardiac progenitor cell named the multipotent Isl1(+) cardiovascular progenitor (MICPs) has been identified, which also expresses Nkx2.5, GATA4, CD34 and Flk1.

Links

PubMed Online version:10.1111/cpr.12024

Keywords

Animals; Antigens, CD34/genetics; Antigens, CD34/metabolism; Biomarkers/metabolism; Cell Differentiation; Cell Lineage; Cell Shape; Cells, Cultured; Chick Embryo; Chickens/genetics; Chickens/growth & development; Chickens/metabolism; Embryonic Stem Cells/cytology; Embryonic Stem Cells/metabolism; Endothelial Cells/cytology; Endothelial Cells/metabolism; Fluorescent Antibody Technique; GATA4 Transcription Factor/genetics; GATA4 Transcription Factor/metabolism; Gene Expression Regulation, Developmental; Heart/embryology; Heart/growth & development; Homeodomain Proteins/genetics; Homeodomain Proteins/metabolism; Myocytes, Cardiac/cytology; Myocytes, Cardiac/metabolism; Myocytes, Smooth Muscle/cytology; Myocytes, Smooth Muscle/metabolism; Real-Time Polymerase Chain Reaction; Transcription Factors/genetics; Transcription Factors/metabolism; Vascular Endothelial Growth Factor Receptor-2/genetics; Vascular Endothelial Growth Factor Receptor-2/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CHICK:E1C9C6

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:F1NC42

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:F1NW21

located_in

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:GATA4

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:ISL1

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:Q677M1

located_in

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:NKX25

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:Q90ZF0

located_in

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:GATA4

part_of

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:ISL1

part_of

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:NKX25

part_of

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:Q677M1

part_of

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:Q90ZF0

part_of

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

Notes

See also

References

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