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PMID:23493556
| Citation |
Wallrapp, FH, Pan, JJ, Ramamoorthy, G, Almonacid, DE, Hillerich, BS, Seidel, R, Patskovsky, Y, Babbitt, PC, Almo, SC, Jacobson, MP and Poulter, CD (2013) Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily. Proc. Natl. Acad. Sci. U.S.A. 110:E1196-202 |
|---|---|
| Abstract |
The number of available protein sequences has increased exponentially with the advent of high-throughput genomic sequencing, creating a significant challenge for functional annotation. Here, we describe a large-scale study on assigning function to unknown members of the trans-polyprenyl transferase (E-PTS) subgroup in the isoprenoid synthase superfamily, which provides substrates for the biosynthesis of the more than 55,000 isoprenoid metabolites. Although the mechanism for determining the product chain length for these enzymes is known, there is no simple relationship between function and primary sequence, so that assigning function is challenging. We addressed this challenge through large-scale bioinformatics analysis of >5,000 putative polyprenyl transferases; experimental characterization of the chain-length specificity of 79 diverse members of this group; determination of 27 structures of 19 of these enzymes, including seven cocrystallized with substrate analogs or products; and the development and successful application of a computational approach to predict function that leverages available structural data through homology modeling and docking of possible products into the active site. The crystallographic structures and computational structural models of the enzyme-ligand complexes elucidate the structural basis of specificity. As a result of this study, the percentage of E-PTS sequences similar to functionally annotated ones (BLAST e-value ≤ 1e(-70)) increased from 40.6 to 68.8%, and the percentage of sequences similar to available crystal structures increased from 28.9 to 47.4%. The high accuracy of our blind prediction of newly characterized enzymes indicates the potential to predict function to the complete polyprenyl transferase subgroup of the isoprenoid synthase superfamily computationally. |
| Links |
PubMed PMC3612614 Online version:10.1073/pnas.1300632110 |
| Keywords |
Alkyl and Aryl Transferases/genetics; Alkyl and Aryl Transferases/metabolism; Carbon-Carbon Ligases/genetics; Carbon-Carbon Ligases/metabolism; Crystallography, X-Ray; Databases, Protein; Molecular Docking Simulation/methods; Sequence Analysis, Protein/methods |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0033384: geranyl diphosphate biosynthetic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004161: dimethylallyltranstransferase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0004161: dimethylallyltranstransferase activity |
ECO:0000314: |
F |
Table S8 in the supplementary information has the assigned annotation. This protein is GI: 158979013. C10 refers to the product of the reaction: geranyl diphosphate. |
complete | ||||
| GO:0033384: geranyl diphosphate biosynthetic process |
ECO:0000314: |
P |
Table S8 in the supplementary information contains the assigned function. This protein is GI: 158979013. This protein is a polyprenyltransferase that catalyses the formation of C10: geranyl diphosphate. |
complete | ||||
|
involved_in |
GO:0045337: farnesyl diphosphate biosynthetic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004337: geranyltranstransferase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0004337: geranyltranstransferase activity |
ECO:0000314: |
F |
The length of the product is provided in table S8 in the supplementary informationn. This protein is GI: 24111799. This protein catalyzes the formation of C15 which stands for farnesyl diphosphate. |
complete | ||||
| GO:0045337: farnesyl diphosphate biosynthetic process |
ECO:0000314: |
P |
Table S8 in the supplemetary information has the length of the product produced. This protein is GI: 24111799. C15 stands for farnesyl diphosphate. |
complete | ||||
|
involved_in |
GO:0045337: farnesyl diphosphate biosynthetic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004337: geranyltranstransferase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0004337: geranyltranstransferase activity |
ECO:0000314: |
F |
The length of the product produced is given in table S8 in the supplementary information. This protein is GI:116333612. C15 stands for farnesyl diphosphate. |
complete | ||||
| GO:0045337: farnesyl diphosphate biosynthetic process |
ECO:0000314: |
P |
Table S8 in the supplementary information contains the length of the product produced. C15 is farnesyl diphosphate. This protein is GI: 116333612. |
complete | ||||
|
involved_in |
GO:0033386: geranylgeranyl diphosphate biosynthetic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004311: farnesyltranstransferase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0004311: farnesyltranstransferase activity |
ECO:0000314: |
F |
Table S8 in the SI contains the length of the prduct produced by this enzyme. This protein is GI: 218766585. The C20 stands for geranylgeranyl diphosphate. |
complete | ||||
| GO:0033386: geranylgeranyl diphosphate biosynthetic process |
ECO:0000314: |
P |
Table S8 in the SI contains the length of the product produced by this enzyme (GI:218766585). The C20 stands for geranylgeranyl diphosphate |
complete | ||||
| GO:0045337: farnesyl diphosphate biosynthetic process |
ECO:0000314: |
P |
The product produced by this enzyme is provided in table s9 in the SI. C15 stands for farnesyl diphosphate. The authors mention in the paper, that they also tried longer substrates than the five carbon substrates, with similar results. |
complete | ||||
| GO:0004337: geranyltranstransferase activity |
ECO:0000314: |
F |
The product of the reaction catalyzed by this enzyme is in table S9 in the SI. C15 stands for farnesyl diphosphate. This protein is GI: 293372070. The authors mention that they use substrates that are longer than the five carbon substrates with similar results. |
complete | ||||
|
involved_in |
GO:0045337: farnesyl diphosphate biosynthetic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004337: geranyltranstransferase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004311: farnesyltranstransferase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0033386: geranylgeranyl diphosphate biosynthetic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0033386: geranylgeranyl diphosphate biosynthetic process |
ECO:0000314: |
P |
The product of the reaction catalyzed by this protein is given in table S9 in the SI. This protein is GI: 52842540. C20 stands for geranylgeranyl diphosphate. The authors mention in the text that they also use longer chains as substrates but saw the same activity. |
complete | ||||
| GO:0004311: farnesyltranstransferase activity |
ECO:0000314: |
F |
This protein is GI: 52842540 in the SI, table S9. C20 stands for geranylgeranyl diphosphate. The authors also mention that they tried longer substrates but found the same activity. |
complete | ||||
|
enables |
GO:0004337: geranyltranstransferase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045337: farnesyl diphosphate biosynthetic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0045337: farnesyl diphosphate biosynthetic process |
ECO:0000314: |
P |
The substrate produced by the rxn catalyzed by this enzyme is in table S9. This protein is GI: 8272412 and C15 stands for farnesyl diphosphate. |
complete | ||||
| GO:0004337: geranyltranstransferase activity |
ECO:0000314: |
F |
The substrate produced by the rxn catalyzed by this enzyme is in table S9. This protein is GI: 8272412 and C15 stands for farnesyl diphosphate. |
complete | ||||
| GO:0045337: farnesyl diphosphate biosynthetic process |
ECO:0000314: |
P |
This protein is GI: 16126308 in table S9 which shows the substrate produced by the rxn catalyzed by this enzyme. C15 stands for farnesyl diphosphate. |
complete | ||||
| GO:0004337: geranyltranstransferase activity |
ECO:0000314: |
F |
This protein is GI: 16126308 in table S9 which shows the substrate produced by the rxn catalyzed by this enzyme. C15 stands for farnesyl diphosphate. |
complete | ||||
|
involved_in |
GO:0045337: farnesyl diphosphate biosynthetic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004337: geranyltranstransferase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0033386: geranylgeranyl diphosphate biosynthetic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004311: farnesyltranstransferase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0033386: geranylgeranyl diphosphate biosynthetic process |
ECO:0000314: |
P |
This protein is GI: 118468511 in table S9 which also lists the product of the rxn catalyzed by this enzyme. C20 stands for geranylgeranyl diphosphate. |
complete | ||||
| GO:0004311: farnesyltranstransferase activity |
ECO:0000314: |
F |
This protein is GI: 118468511 in table S9 which also lists the product of the rxn catalyzed by this enzyme. C20 stands for geranylgeranyl diphosphate. |
complete | ||||
|
enables |
GO:0004337: geranyltranstransferase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045337: farnesyl diphosphate biosynthetic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0045337: farnesyl diphosphate biosynthetic process |
ECO:0000314: |
P |
This protein is GI: 104774286 in table S9 in which C15 is listed as the product of the rxn catalyzed by this enzyme. C15 stands for farnesyl diphosphate. |
complete | ||||
| GO:0004337: geranyltranstransferase activity |
ECO:0000314: |
F |
This protein is GI: 104774286 in table S9 in which C15 is listed as the product of the rxn catalyzed by this enzyme. C15 stands for farnesyl diphosphate. |
complete | ||||
|
involved_in |
GO:0045337: farnesyl diphosphate biosynthetic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004337: geranyltranstransferase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0045337: farnesyl diphosphate biosynthetic process |
ECO:0000314: |
P |
This protein is GI: 58337602 in table S9 which lists C15 as the product of the rxn catalyzed by this enzyme. C15 stands for farnesyl diphosphate |
complete | ||||
| GO:0004337: geranyltranstransferase activity |
ECO:0000314: |
F |
This protein is GI: 58337602 in table S9 which lists C15 as the product of the rxn catalyzed by this enzyme. C15 stands for farnesyl diphosphate |
complete | ||||
|
enables |
GO:0004311: farnesyltranstransferase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0033386: geranylgeranyl diphosphate biosynthetic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0033386: geranylgeranyl diphosphate biosynthetic process |
ECO:0000314: |
P |
Table S9 lists the product of the rxn catalyzed by this enzyme. THis enzyme is GI: 39934591 and C20 stands for geranylgeranyl diphosphate |
complete | ||||
| GO:0004311: farnesyltranstransferase activity |
ECO:0000314: |
F |
Table S9 lists the product of the rxn catalyzed by this enzyme. This enzyme is GI: 39934591 and C20 stands for geranylgeranyl diphosphate |
complete | ||||
|
enables |
GO:0004337: geranyltranstransferase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045337: farnesyl diphosphate biosynthetic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0045337: farnesyl diphosphate biosynthetic process |
ECO:0000314: |
P |
Table S10 lists the length of the product produced by the rxn catalyzed by this enzyme. This enzyme is GI: 53804815 and C15 stands for farnesyl diphosphate |
complete | ||||
| GO:0004337: geranyltranstransferase activity |
ECO:0000314: |
F |
Table S10 lists the length of the product produced by the rxn catalyzed by this enzyme. This enzyme is GI: 53804815 and C15 stands for farnesyl diphosphate |
complete | ||||
|
involved_in |
GO:0045337: farnesyl diphosphate biosynthetic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004337: geranyltranstransferase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0045337: farnesyl diphosphate biosynthetic process |
ECO:0000314: |
P |
The length of the product produced by the rxn catalyzed by this enzyme is provided in table S10. This protein is GI: 18310802. C15 stands for farnesyl diphosphate |
complete | ||||
| GO:0004337: geranyltranstransferase activity |
ECO:0000314: |
F |
The length of the product produced by the rxn catalyzed y this enzyme is given in table S10. This protein is GI: 18310802 and C15 stands for farnesyl diphosphate. |
complete | ||||
|
involved_in |
GO:0033386: geranylgeranyl diphosphate biosynthetic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004311: farnesyltranstransferase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0033386: geranylgeranyl diphosphate biosynthetic process |
ECO:0000314: |
P |
The length of the product produced is listed in table S10. This protein is GI: 55979982. C20 stands for geranylgeranyl diphosphate. |
complete | ||||
| GO:0004311: farnesyltranstransferase activity |
ECO:0000314: |
F |
The length of the product is given in table S10. This protein is GI: 55979982. C20 stands for geranylgeranyl diphosphate. |
complete | ||||
|
involved_in |
GO:0033386: geranylgeranyl diphosphate biosynthetic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004311: farnesyltranstransferase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0033386: geranylgeranyl diphosphate biosynthetic process |
ECO:0000314: |
P |
The length of the product produced in the rxn catalyzed by this enzyme is proovided in table S10. This protein is GI: 15642935. C20 stands for geranylgeranyl diphosphate |
complete | ||||
| GO:0004311: farnesyltranstransferase activity |
ECO:0000314: |
F |
The length of the product produced in the rxn catalyzed by this enzyme is proovided in table S10. This protein is GI: 15642935. C20 stands for geranylgeranyl diphosphate |
complete | ||||
|
involved_in |
GO:0045337: farnesyl diphosphate biosynthetic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004337: geranyltranstransferase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0045337: farnesyl diphosphate biosynthetic process |
ECO:0000314: |
P |
The length of the product produced is given in table S10. This protein is GI: 34557991. C15 stands for farnesyl diphosphate |
complete | ||||
| GO:0004337: geranyltranstransferase activity |
ECO:0000314: |
F |
The length of the product produced is given in table S10. This protein is GI: 34557991. C15 stands for farnesyl diphosphate |
complete | ||||
|
enables |
GO:0004337: geranyltranstransferase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045337: farnesyl diphosphate biosynthetic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0045337: farnesyl diphosphate biosynthetic process |
ECO:0000314: |
P |
The length of the product is given in table S9. THis protein is GI: 15837263. C15 stands for farnesyl diphosphate |
complete | ||||
| GO:0004337: geranyltranstransferase activity |
ECO:0000314: |
F |
The length of the product is given in table S9. THis protein is GI: 15837263. C15 stands for farnesyl diphosphate |
complete | ||||
| GO:0045337: farnesyl diphosphate biosynthetic process |
ECO:0000314: |
P |
The length of the product produced is given in table S10. This protein is GI: 33600896, and C15 stands for farnesyl diphosphate |
complete | ||||
| GO:0004337: geranyltranstransferase activity |
ECO:0000314: |
F |
The length of the product produced is given in table S10. This protein is GI: 33600896, and C15 stands for farnesyl diphosphate |
complete | ||||
|
enables |
GO:0004337: geranyltranstransferase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045337: farnesyl diphosphate biosynthetic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0045337: farnesyl diphosphate biosynthetic process |
ECO:0000314: |
P |
The length of the product produced by the rxn catalyzed by this enzyme is given in table S10. This protein is GI: 152991761 and C15 stands for farnesyl diphosphate |
complete | ||||
| GO:0004337: geranyltranstransferase activity |
ECO:0000314: |
F |
The length of the product produced by the rxn catalyzed by this enzyme is given in table S10. This protein is GI: 152991761 and C15 stands for farnesyl diphosphate |
complete | ||||
|
enables |
GO:0004337: geranyltranstransferase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045337: farnesyl diphosphate biosynthetic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0045337: farnesyl diphosphate biosynthetic process |
ECO:0000314: |
P |
The length of the product produced is provided in table S10. This protein is GI: 17546941 and C15 stands for farnesyl diphosphate |
complete | ||||
| GO:0004337: geranyltranstransferase activity |
ECO:0000314: |
F |
The length of the product produced is provided in table S10. This protein is GI: 17546941 and C15 stands for farnesyl diphosphate |
complete | ||||
| GO:0045337: farnesyl diphosphate biosynthetic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
The length of the product produced is given in table S10. This protein is GI: 16800468 and C15 stands for farnesyl diphosphate. |
complete | ||||
| GO:0004337: geranyltranstransferase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
The length of the product produced is given in table S10. This protein is GI: 16800468 and C15 stands for farnesyl diphosphate. |
complete | ||||
| GO:0033386: geranylgeranyl diphosphate biosynthetic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
The length of the product is given in table S10. This protein is GI: 40062988 and C20 stands for geranylgeranyl diphosphate |
complete | ||||
| GO:0004311: farnesyltranstransferase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
The length of the product is given in table S10. This protein is GI: 40062988 and C20 stands for geranylgeranyl diphosphate |
complete | ||||
|
involved_in |
GO:0033386: geranylgeranyl diphosphate biosynthetic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004311: farnesyltranstransferase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0033386: geranylgeranyl diphosphate biosynthetic process |
ECO:0000314: |
P |
The length of the product is provided in table S10. THis protein is GI: 149238027 and C20 stands for geranylgeranyl diphosphate. |
complete | ||||
| GO:0004311: farnesyltranstransferase activity |
ECO:0000314: |
F |
The length of the product is provided in table S10. THis protein is GI: 149238027 and C20 stands for geranylgeranyl diphosphate. |
complete | ||||
| GO:0033386: geranylgeranyl diphosphate biosynthetic process |
ECO:0000314: |
P |
The length of the product produced by the rxn catalyzed by this enzyme is given in table S10. This protein is GI: 63034220 and C20 stands for geranylgeranyl diphosphate |
complete | ||||
| GO:0004311: farnesyltranstransferase activity |
ECO:0000314: |
F |
The length of the product produced by the rxn catalyzed by this enzyme is given in table S10. This protein is GI: 63034220 and C20 stands for geranylgeranyl diphosphate |
complete | ||||
|
involved_in |
GO:0033386: geranylgeranyl diphosphate biosynthetic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004311: farnesyltranstransferase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0033386: geranylgeranyl diphosphate biosynthetic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
The length of the product is given in table S10. This protein is GI: 154151748 and C20 stands for geranylgeranyl diphosphate. |
complete | ||||
| GO:0004311: farnesyltranstransferase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
The length of the product is given in table S10. This protein is GI: 154151748 and C20 stands for geranylgeranyl diphosphate. |
complete | ||||
| GO:0045337: farnesyl diphosphate biosynthetic process |
ECO:0000314: |
P |
The length of the product produced by the rxn catalyzed by this enzyme is given in table S10. This protein is GI: 58584994 and C15 stands for farnesyl diphosphate |
complete | ||||
| GO:0004337: geranyltranstransferase activity |
ECO:0000314: |
F |
The length of the product produced by the rxn catalyzed by this enzyme is given in table S10. This protein is GI: 58584994 and C15 stands for farnesyl diphosphate |
complete | ||||
|
involved_in |
GO:0045337: farnesyl diphosphate biosynthetic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004337: geranyltranstransferase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004311: farnesyltranstransferase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0033386: geranylgeranyl diphosphate biosynthetic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0033386: geranylgeranyl diphosphate biosynthetic process |
ECO:0000314: |
P |
The length of the product produced is given in table S10. This protein is GI: 21673095 and C20 stands for geranylgeranyl diphosphate |
complete | ||||
| GO:0004311: farnesyltranstransferase activity |
ECO:0000314: |
F |
The length of the product produced is given in table S10. This protein is GI: 21673095 and C20 stands for geranylgeranyl diphosphate |
complete | ||||
| GO:0033386: geranylgeranyl diphosphate biosynthetic process |
ECO:0000314: |
P |
tHE LENGTh of the product is provided in table S10. This protein is GI: 126458776. C20 stands for geranylgeranyl diphosphate |
complete | ||||
| GO:0004311: farnesyltranstransferase activity |
ECO:0000314: |
F |
tHE LENGTh of the product is provided in table S10. This protein is GI: 126458776. C20 stands for geranylgeranyl diphosphate |
complete | ||||
|
involved_in |
GO:0033386: geranylgeranyl diphosphate biosynthetic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004311: farnesyltranstransferase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0033386: geranylgeranyl diphosphate biosynthetic process |
ECO:0000314: |
P |
The length of the product produced by this enzyme is given in table S10. This protein is GI: 68489506 and C20 stands for geranylgeranyl diphosphate |
complete | ||||
| GO:0004311: farnesyltranstransferase activity |
ECO:0000314: |
F |
The length of the product produced by this enzyme is given in table S10. This protein is GI: 68489506 and C20 stands for geranylgeranyl diphosphate |
complete | ||||
|
involved_in |
GO:0033386: geranylgeranyl diphosphate biosynthetic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004311: farnesyltranstransferase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
Notes
See also
References
See Help:References for how to manage references in GONUTS.
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