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PMID:23426196

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Citation

Jégu, T, Latrasse, D, Delarue, M, Mazubert, C, Bourge, M, Hudik, E, Blanchet, S, Soler, MN, Charon, C, De Veylder, L, Raynaud, C, Bergounioux, C and Benhamed, M (2013) Multiple functions of Kip-related protein5 connect endoreduplication and cell elongation. Plant Physiol. 161:1694-705

Abstract

Despite considerable progress in our knowledge regarding the cell cycle inhibitor of the Kip-related protein (KRP) family in plants, less is known about the coordination of endoreduplication and cell differentiation. In animals, the role of cyclin-dependent kinase (CDK) inhibitors as multifunctional factors coordinating cell cycle regulation and cell differentiation is well documented and involves not only the inhibition of CDK/cyclin complexes but also other mechanisms, among them the regulation of transcription. Interestingly, several plant KRPs have a punctuated distribution in the nucleus, suggesting that they are associated with heterochromatin. Here, one of these chromatin-bound KRPs, KRP5, has been studied in Arabidopsis (Arabidopsis thaliana). KRP5 is expressed in endoreduplicating cells, and loss of KRP5 function decreases endoreduplication, indicating that KRP5 is a positive regulator of endoreduplication. This regulation relies on several mechanisms: in addition to its role in cyclin/CDK kinase inhibition previously described, chromatin immunoprecipitation sequencing data combined with transcript quantification provide evidence that KRP5 regulates the transcription of genes involved in cell wall organization. Furthermore, KRP5 overexpression increases chromocenter decondensation and endoreduplication in the Arabidopsis trithorax-related protein5 (atxr5) atxr6 double mutant, which is deficient for the deposition of heterochromatin marks. Hence, KRP5 could bind chromatin to coordinately control endoreduplication and chromatin structure and allow the expression of genes required for cell elongation.

Links

PubMed PMC3613449 Online version:10.1104/pp.112.212357

Keywords


Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

ARATH:KRP5

GO:0032877: positive regulation of DNA endoreduplication

ECO:0000315:

P

Fig2B

complete
CACAO 8488

ARATH:KRP5

GO:0031490: chromatin DNA binding

ECO:0000314:

F

Figure 4

complete
CACAO 8491

ARATH:KRP5

enables

GO:0031490: chromatin DNA binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

ARATH:KRP5

involved_in

GO:0032877: positive regulation of DNA endoreduplication

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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