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PMID:23037713
| Citation |
Dibb, M, Han, N, Choudhury, J, Hayes, S, Valentine, H, West, C, Ang, YS and Sharrocks, AD (2012) The FOXM1-PLK1 axis is commonly upregulated in oesophageal adenocarcinoma. Br. J. Cancer 107:1766-75 |
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| Abstract |
The transcription factor FOXM1 is an important regulator of the cell cycle through controlling periodic gene expression during the G2 and M phases. One key target for FOXM1 is the gene encoding the protein kinase PLK1 and PLK1 itself acts in a positive feedback loop to phosphorylate and activate FOXM1. Both FOXM1 and PLK1 have been shown to be overexpressed in a variety of different tumour types. |
| Links |
PubMed PMC3493860 Online version:10.1038/bjc.2012.424 |
| Keywords |
Adenocarcinoma/genetics; Adenocarcinoma/metabolism; Cell Cycle Proteins/biosynthesis; Cell Cycle Proteins/genetics; Cell Cycle Proteins/metabolism; Cell Line, Tumor; Cohort Studies; Esophageal Neoplasms/genetics; Esophageal Neoplasms/metabolism; Forkhead Transcription Factors/biosynthesis; Forkhead Transcription Factors/genetics; Forkhead Transcription Factors/metabolism; Gene Expression Regulation, Neoplastic; Humans; Prognosis; Protein-Serine-Threonine Kinases/biosynthesis; Protein-Serine-Threonine Kinases/genetics; Protein-Serine-Threonine Kinases/metabolism; Proto-Oncogene Proteins/biosynthesis; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/metabolism; Up-Regulation |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
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See also
References
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