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PMID:22949614

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Citation

Fujihara, Y, Satouh, Y, Inoue, N, Isotani, A, Ikawa, M and Okabe, M (2012) SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia. Development 139:3583-9

Abstract

SPACA1 is a membrane protein that localizes in the equatorial segment of spermatozoa in mammals and is reported to function in sperm-egg fusion. We produced a Spaca1 gene-disrupted mouse line and found that the male mice were infertile. The cause of this sterility was abnormal shaping of the sperm head reminiscent of globozoospermia in humans. Disruption of Spaca1 led to the disappearance of the nuclear plate, a dense lining of the nuclear envelope facing the inner acrosomal membrane. This coincided with the failure of acrosomal expansion during spermiogenesis and resulted in the degeneration and disappearance of the acrosome in mature spermatozoa. Thus, these findings clarify part of the cascade leading to globozoospermia.

Links

PubMed Online version:10.1242/dev.081778

Keywords


Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:SACA1

located_in

GO:0002080: acrosomal membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:SACA1

involved_in

GO:0007283: spermatogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:5439282

P

Seeded From UniProt

complete

MOUSE:SACA1

involved_in

GO:0001675: acrosome assembly

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:5439282

P

Seeded From UniProt

complete


See also

References

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