GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:22885984

From GONUTS
Jump to: navigation, search
Citation

van Gisbergen, KP, Kragten, NA, Hertoghs, KM, Wensveen, FM, Jonjic, S, Hamann, J, Nolte, MA and van Lier, RA (2012) Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation. Nat. Immunol. 13:864-71

Abstract

The transcriptional repressor Blimp-1 mediates the terminal differentiation of many cell types, including T cells. Here we identified Hobit (Znf683) as a previously unrecognized homolog of Blimp-1 that was specifically expressed in mouse natural killer T cells (NKT cells). Through studies of Hobit-deficient mice, we found that Hobit was essential for the formation of mature thymic NKT cells. In the periphery, Hobit repressed the accumulation of interferon-γ (IFN-γ)-producing NK1.1(lo) NKT cells at steady state. After antigenic stimulation, Hobit repressed IFN-γ expression, whereas after innate stimulation, Hobit induced granzyme B expression. Thus, reminiscent of the function of Blimp-1 in other lymphocytes, Hobit controlled the maintenance of quiescent, fully differentiated NKT cells and regulated their immediate effector functions.

Links

PubMed Online version:10.1038/ni.2393

Keywords

Amino Acid Sequence; Animals; Cell Differentiation/genetics; Cell Differentiation/immunology; Flow Cytometry; Mice; Mice, Knockout; Molecular Sequence Data; Natural Killer T-Cells/cytology; Natural Killer T-Cells/immunology; Phylogeny; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors/genetics

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:ZN683

involved_in

GO:0032826: regulation of natural killer cell differentiation involved in immune response

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:ZN683

involved_in

GO:0010468: regulation of gene expression

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:ZN683

acts_upstream_of_or_within

GO:0001779: natural killer cell differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:4276801

P

  • occurs_in:(EMAPA:18768)
  • results_in_acquisition_of_features_of:(CL:0000814)

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.