PMID:22869741

Citation	Eloy, NB, Gonzalez, N, Van Leene, J, Maleux, K, Vanhaeren, H, De Milde, L, Dhondt, S, Vercruysse, L, Witters, E, Mercier, R, Cromer, L, Beemster, GT, Remaut, H, Van Montagu, MC, De Jaeger, G, Ferreira, PC and Inzé, D (2012) SAMBA, a plant-specific anaphase-promoting complex/cyclosome regulator is involved in early development and A-type cyclin stabilization. Proc. Natl. Acad. Sci. U.S.A. 109:13853-8
Abstract	The anaphase-promoting complex/cyclosome (APC/C) is a large multiprotein E3 ubiquitin ligase involved in ubiquitin-dependent proteolysis of key cell cycle regulatory proteins, including the destruction of mitotic cyclins at the metaphase-to-anaphase transition. Despite its importance, the role of the APC/C in plant cells and the regulation of its activity during cell division remain poorly understood. Here, we describe the identification of a plant-specific negative regulator of the APC/C complex, designated SAMBA. In Arabidopsis thaliana, SAMBA is expressed during embryogenesis and early plant development and plays a key role in organ size control. Samba mutants produced larger seeds, leaves, and roots, which resulted from enlarged root and shoot apical meristems, and, additionally, they had a reduced fertility attributable to a hampered male gametogenesis. Inactivation of SAMBA stabilized A2-type cyclins during early development. Our data suggest that SAMBA regulates cell proliferation during early development by targeting CYCLIN A2 for APC/C-mediated proteolysis.
Links	PubMed PMC3427114 Online version:10.1073/pnas.1211418109
Keywords
edit table

Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
ARATH:SAMBA	enables	GO:0010997: anaphase-promoting complex binding	ECO:0000314: direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
ARATH:SAMBA	acts_upstream_of_or_within	GO:0045732: positive regulation of protein catabolic process	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
ARATH:SAMBA	acts_upstream_of_or_within	GO:0046621: negative regulation of organ growth	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
ARATH:SAMBA	acts_upstream_of_or_within	GO:0009555: pollen development	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
ARATH:SAMBA	acts_upstream_of_or_within	GO:0009556: microsporogenesis	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete

References

See Help:References for how to manage references in GONUTS.