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PMID:2271648

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Citation

Barnett, TR, Pickle, W 2nd and Elting, JJ (1990) Characterization of two new members of the pregnancy-specific beta 1-glycoprotein family from the myeloid cell line KG-1 and suggestion of two distinct classes of transcription unit. Biochemistry 29:10213-8

Abstract

Pregnancy-specific beta 1-glycoproteins (PSGs) represent a large group (approximately 12-15) of proteins, related to members of the carcinoembryonic antigen family, that are abundant in placental tissue and in the sera of pregnant women. We describe the isolation and characterization of two additional PSG cDNAs, PSG9 and PSG10, whose transcripts are largely expressed in placental tissue and to a lesser extent in some other cell types, including myeloid cells differentiated to granulocytes. PSG9 and PSG10 are representatives of two distinct classes of PSG protein that have N-termini with or without the Arg-Gly-Asp motif implicated in adhesion. In addition to this distinction at the amino acid level, our analysis of several PSG cDNAs suggests that the transcription units encoding these proteins may be further distinguished in their 3' untranslated sequences, thus suggesting possibilities for transcriptional regulation of the two major protein classes.

Links

PubMed

Keywords

Amino Acid Sequence; Base Sequence; Cell Differentiation/drug effects; DNA/genetics; DNA, Neoplasm/genetics; Female; Granulocytes; Hematopoietic Stem Cells/chemistry; Humans; Leukemia/pathology; Male; Molecular Sequence Data; Multigene Family; Neoplasm Proteins/genetics; Neoplasm Proteins/isolation & purification; Neoplastic Stem Cells/chemistry; Oligopeptides/analysis; Pregnancy-Specific beta 1-Glycoproteins/classification; Pregnancy-Specific beta 1-Glycoproteins/genetics; Pregnancy-Specific beta 1-Glycoproteins/isolation & purification; RNA, Messenger/biosynthesis; RNA, Messenger/genetics; RNA, Neoplasm/biosynthesis; Sequence Homology, Nucleic Acid; Transcription, Genetic; Tumor Cells, Cultured/chemistry

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:PSG6

located_in

GO:0005576: extracellular region

ECO:0000303: author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

HUMAN:PSG6

involved_in

GO:0007565: female pregnancy

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

HUMAN:PSG6

part_of

GO:0005576: extracellular region

ECO:0000303: author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete


See also

References

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