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PMID:22712556

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Citation

Sreesankar, E, Senthilkumar, R, Bharathi, V, Mishra, RK and Mishra, K (2012) Functional diversification of yeast telomere associated protein, Rif1, in higher eukaryotes. BMC Genomics 13:255

Abstract

Telomeres are nucleoprotein complexes at the end of linear eukaryotic chromosomes which maintain the genome integrity by regulating telomere length, preventing recombination and end to end fusion events. Multiple proteins associate with telomeres and function in concert to carry out these functions. Rap1 interacting factor 1 (Rif1), was identified as a protein involved in telomere length regulation in yeast. Rif1 is conserved upto mammals but its function has diversified from telomere length regulation to maintenance of genome integrity.

Links

PubMed PMC3410773 Online version:10.1186/1471-2164-13-255

Keywords

Animals; Computational Biology; DNA Damage; Drosophila Proteins/antagonists & inhibitors; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila melanogaster/metabolism; Evolution, Molecular; HeLa Cells; Humans; Phylogeny; Protein Binding; Protein Phosphatase 1/chemistry; Protein Phosphatase 1/metabolism; RNA Interference; RNA, Small Interfering/metabolism; Repressor Proteins/classification; Repressor Proteins/genetics; Repressor Proteins/metabolism; Retroelements; Saccharomyces cerevisiae/metabolism; Saccharomyces cerevisiae Proteins/classification; Saccharomyces cerevisiae Proteins/genetics; Saccharomyces cerevisiae Proteins/metabolism; Telomere/metabolism; Telomere-Binding Proteins/classification; Telomere-Binding Proteins/genetics; Telomere-Binding Proteins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:RIF1

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:RIF1

located_in

GO:0000792: heterochromatin

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete


See also

References

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