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PMID:2257629

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Citation

Han, M and Sternberg, PW (1990) let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein. Cell 63:921-31

Abstract

Genetic analysis previously suggested that the let-60 gene controls the switch between vulval and hypodermal cell fates during C. elegans vulval induction. We have cloned the let-60 gene, and shown that it encodes a gene product identical in 84% of its first 164 amino acids to ras gene products from other vertebrate and invertebrate species. This conservation suggests that the let-60 product contains all the biochemical functions of ras proteins. Extrachromosomal arrays of let-60 ras DNA cause cell-type misspecification (extra vulval fates) phenotypically opposite to that caused by let-60 ras loss-of-function mutations (no vulval fates), and suppress the vulvaless phenotype of mutations in two other genes necessary for vulval induction. Thus, the level and pattern of let-60 ras expression may be under strict regulation; increase in let-60 ras activity bypasses or reduces the need for upstream genes in the vulval induction pathway.

Links

PubMed

Keywords

Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Caenorhabditis/embryology; Caenorhabditis/genetics; Caenorhabditis elegans Proteins; Cloning, Molecular; Cosmids; DNA/genetics; DNA/isolation & purification; Disorders of Sex Development; Embryo, Nonmammalian; Female; Genes, ras; Helminth Proteins/genetics; Models, Biological; Molecular Sequence Data; Plasmids; Restriction Mapping; Sequence Homology, Nucleic Acid; Signal Transduction; Transcription, Genetic; Vulva/embryology; ras Proteins

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CAEEL:LET60

involved_in

GO:0007173: epidermal growth factor receptor signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00002299

P

Seeded From UniProt

complete


See also

References

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