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PMID:22284121

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Citation

Jones, PH, Mehta, HV, Maric, M, Roller, RJ and Okeoma, CM (2012) Bone marrow stromal cell antigen 2 (BST-2) restricts mouse mammary tumor virus (MMTV) replication in vivo. Retrovirology 9:10

Abstract

Bone marrow stromal cell antigen 2 (BST-2) is a cellular factor that restricts the egress of viruses such as human immunodeficiency virus (HIV-1) from the surface of infected cells, preventing infection of new cells. BST-2 is variably expressed in most cell types, and its expression is enhanced by cytokines such as type I interferon alpha (IFN-α). In this present study, we used the beta-retrovirus, mouse mammary tumor virus (MMTV) as a model to examine the role of mouse BST-2 in host infection in vivo.

Links

PubMed PMC3283513 Online version:10.1186/1742-4690-9-10

Keywords

Animals; Antigens, CD/metabolism; Cell Line; Gene Silencing; Mammary Tumor Virus, Mouse/immunology; Mammary Tumor Virus, Mouse/physiology; Membrane Glycoproteins/metabolism; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; RNA Interference; Virus Release

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:BST2

located_in

GO:0009986: cell surface

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:BST2

involved_in

GO:0009615: response to virus

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:BST2

involved_in

GO:0045071: negative regulation of viral genome replication

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:BST2

involved_in

GO:0035455: response to interferon-alpha

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:BST2

involved_in

GO:1901253: negative regulation of intracellular transport of viral material

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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