GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:22110599

From GONUTS
Jump to: navigation, search
Citation

Zhong, Y, Shtineman-Kotler, A, Nguyen, L, Iliadi, KG, Boulianne, GL and Rotin, D (2011) A splice isoform of DNedd4, DNedd4-long, negatively regulates neuromuscular synaptogenesis and viability in Drosophila. PLoS ONE 6:e27007

Abstract

Neuromuscular (NM) synaptogenesis is a tightly regulated process. We previously showed that in flies, Drosophila Nedd4 (dNedd4/dNedd4S) is required for proper NM synaptogenesis by promoting endocytosis of commissureless from the muscle surface, a pre-requisite step for muscle innervation. DNedd4 is an E3 ubiquitin ligase comprised of a C2-WW(x3)-Hect domain architecture, which includes several splice isoforms, the most prominent ones are dNedd4-short (dNedd4S) and dNedd4-long (dNedd4Lo).

Links

PubMed PMC3215714 Online version:10.1371/journal.pone.0027007

Keywords

Animals; Biocatalysis; Drosophila melanogaster/genetics; Drosophila melanogaster/metabolism; Drosophila melanogaster/physiology; Endosomal Sorting Complexes Required for Transport/genetics; Endosomal Sorting Complexes Required for Transport/metabolism; Gene Expression Regulation; Larva/metabolism; Larva/physiology; Locomotion; Muscles/metabolism; Muscles/physiology; Mutation; Neuromuscular Junction/metabolism; Protein Isoforms/genetics; Protein Isoforms/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Ubiquitin-Protein Ligases/genetics; Ubiquitin-Protein Ligases/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:NEDD4

located_in

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:NEDD4

involved_in

GO:0007528: neuromuscular junction development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:NEDD4

located_in

GO:0005886: plasma membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.