PMID:22058142

Citation	Barba-Ostria, C, Lledías, F and Georgellis, D (2011) The Neurospora crassa DCC-1 protein, a putative histidine kinase, is required for normal sexual and asexual development and carotenogenesis. Eukaryotic Cell 10:1733-9
Abstract	Two-component signaling pathways based on phosphoryl group transfer between histidine kinase and response regulator proteins regulate environmental responses in bacteria, archaea, plants, slime molds, and fungi. Here we characterize a mutant form of DCC-1, a putative histidine kinase encoded by the NCU00939 gene of the filamentous fungus Neurospora crassa. We show that this protein participates in the regulation of processes such as conidiation, perithecial development, and, to a certain degree, carotenogenesis. Furthermore, DCC-1 is suggested to exert its effect by promoting cyclic AMP production, thereby placing this protein within the context of a signaling pathway.
Links	PubMed PMC3232730 Online version:10.1128/EC.05223-11
Keywords	Carotenoids/biosynthesis; Circadian Rhythm; Cyclic AMP/biosynthesis; Fungal Proteins/genetics; Fungal Proteins/metabolism; Fungal Proteins/physiology; Gene Knockout Techniques; Morphogenesis; Neurospora crassa/enzymology; Neurospora crassa/genetics; Neurospora crassa/growth & development; Phenotype; Protein Kinases/genetics; Protein Kinases/metabolism; Protein Kinases/physiology; Reproduction, Asexual; Signal Transduction; Spores, Fungal/enzymology; Spores, Fungal/genetics; Spores, Fungal/growth & development
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
NEUCR:Q7SFA8		GO:0075308: negative regulation of conidium formation	ECO:0000315:		P		Figure 3A shows that the DCC1 mutant has increased conidia	complete CACAO 5993
NEUCR:Q7SFA8	involved_in	GO:0075308: negative regulation of conidium formation	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete

References

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