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PMID:22041576

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Citation

Marygold, SJ, Walker, C, Orme, M and Leevers, S (2011) Genetic characterization of ebi reveals its critical role in Drosophila wing growth. Fly (Austin) 5

Abstract

The ebi gene of Drosophila melanogaster has been implicated in diverse signalling pathways, cellular functions and developmental processes. However, a thorough genetic analysis of this gene has been lacking and the true extent of its biological roles is unclear. Here, we characterize eleven ebi mutations and find that ebi has a novel role in promoting growth of the wing imaginal disc: viable combinations of mutant alleles give rise to adults with small wings. Wing discs with reduced EBI levels are correspondingly small and exhibit down-regulation of Notch target genes. Furthermore, we show that EBI colocalizes on polytene chromosomes with Smrter (SMR), a transcriptional corepressor, and Suppressor of Hairless (SU(H)), the primary transcription factor involved in Notch signalling. Interestingly, the mammalian orthologs of ebi, transducin β-like 1 (TBL1) and TBL-related 1 (TBLR1), function as corepressor/coactivator exchange factors and are required for transcriptional activation of Notch target genes. We hypothesize that EBI acts to activate (de-repress) transcription of Notch target genes important for Drosophila wing growth by functioning as a corepressor/coactivator exchange factor for SU(H).

Links

PubMed PMC3266070

Keywords


Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:M9PGZ8

located_in

GO:0005700: polytene chromosome

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:SUH

located_in

GO:0005700: polytene chromosome

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:EBI

involved_in

GO:0022416: chaeta development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:EBI

located_in

GO:0005700: polytene chromosome

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:EBI

involved_in

GO:0045747: positive regulation of Notch signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:EBI

involved_in

GO:0045747: positive regulation of Notch signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0004647

P

Seeded From UniProt

complete

DROME:EBI

involved_in

GO:0045572: positive regulation of imaginal disc growth

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:EBI

involved_in

GO:0045572: positive regulation of imaginal disc growth

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0004569

P

Seeded From UniProt

complete

DROME:EBI

involved_in

GO:0045572: positive regulation of imaginal disc growth

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0015279

P

Seeded From UniProt

complete

DROME:EBI

involved_in

GO:0035220: wing disc development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:EBI

involved_in

GO:0035220: wing disc development

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0004647

P

Seeded From UniProt

complete

DROME:EBI

involved_in

GO:0035220: wing disc development

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0003975

P

Seeded From UniProt

complete

DROME:EBI

involved_in

GO:0035220: wing disc development

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0003345

P

Seeded From UniProt

complete


See also

References

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