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PMID:22028883

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Citation

Huang, KY, Chen, GD, Cheng, CH, Liao, KY, Hung, CC, Chang, GD, Hwang, PP, Lin, SY, Tsai, MC, Khoo, KH, Lee, MT and Huang, CJ (2011) Phosphorylation of the zebrafish M6Ab at serine 263 contributes to filopodium formation in PC12 cells and neurite outgrowth in zebrafish embryos. PLoS ONE 6:e26461

Abstract

Mammalian M6A, a member of the proteolipid protein (PLP/DM20) family expressed in neurons, was first isolated by expression cloning with a monoclonal antibody. Overexpression of M6A was shown to induce filopodium formation in neuronal cells; however, the underlying mechanism of is largely unknown. Possibly due to gene duplication, there are two M6A paralogs, M6Aa and M6Ab, in the zebrafish genome. In the present study, we used the zebrafish as a model system to investigate the role of zebrafish M6Ab in filopodium formation in PC12 cells and neurite outgrowth in zebrafish embryos.

Links

PubMed PMC3197635 Online version:10.1371/journal.pone.0026461

Keywords

Amino Acid Sequence; Animals; COS Cells; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism; Cercopithecus aethiops; Embryo, Nonmammalian/cytology; Embryo, Nonmammalian/drug effects; Embryo, Nonmammalian/metabolism; Glycoproteins/chemistry; Glycoproteins/genetics; Glycoproteins/metabolism; MAP Kinase Kinase 1/metabolism; MAP Kinase Kinase 2/metabolism; Membrane Glycoproteins/chemistry; Membrane Glycoproteins/genetics; Membrane Glycoproteins/metabolism; Molecular Sequence Data; Nerve Growth Factor/pharmacology; Neurites/drug effects; Neurites/metabolism; PC12 Cells; Phosphorylation/drug effects; Pseudopodia/drug effects; Pseudopodia/metabolism; Rats; Serine/metabolism; Signal Transduction/drug effects; Zebrafish/embryology; Zebrafish Proteins/chemistry; Zebrafish Proteins/genetics; Zebrafish Proteins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DANRE:A1L281

enables

GO:0016301: kinase activity

ECO:0000315: mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

DANRE:A2BGW3

enables

GO:0016301: kinase activity

ECO:0000315: mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

DANRE:E9QDQ2

enables

GO:0016301: kinase activity

ECO:0000315: mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

DANRE:F1QEL7

involved_in

GO:0031175: neuron projection development

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:F1QEL7

involved_in

GO:0051489: regulation of filopodium assembly

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:F8W2C7

involved_in

GO:0031175: neuron projection development

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:F8W2C7

involved_in

GO:0051489: regulation of filopodium assembly

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:Q6DI17

involved_in

GO:0031175: neuron projection development

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:Q6DI17

involved_in

GO:0051489: regulation of filopodium assembly

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:Q8UUS9

involved_in

GO:0031175: neuron projection development

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:Q8UUS9

involved_in

GO:0051489: regulation of filopodium assembly

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:Q8UUT1

involved_in

GO:0031175: neuron projection development

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:Q8UUT1

involved_in

GO:0051489: regulation of filopodium assembly

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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