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PMID:22016187

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Citation

Swartz, ME, Sheehan-Rooney, K, Dixon, MJ and Eberhart, JK (2011) Examination of a palatogenic gene program in zebrafish. Dev. Dyn. 240:2204-20

Abstract

Human palatal clefting is debilitating and difficult to rectify surgically. Animal models enhance our understanding of palatogenesis and are essential in strategies designed to ameliorate palatal malformations in humans. Recent studies have shown that the zebrafish palate, or anterior neurocranium, is under similar genetic control to the amniote palatal skeleton. We extensively analyzed palatogenesis in zebrafish to determine the similarity of gene expression and function across vertebrates. By 36 hours postfertilization (hpf) palatogenic cranial neural crest cells reside in homologous regions of the developing face compared with amniote species. Transcription factors and signaling molecules regulating mouse palatogenesis are expressed in similar domains during palatogenesis in zebrafish. Functional investigation of a subset of these genes, fgf10a, tgfb2, pax9, and smad5 revealed their necessity in zebrafish palatogenesis. Collectively, these results suggest that the gene regulatory networks regulating palatogenesis may be conserved across vertebrate species, demonstrating the utility of zebrafish as a model for palatogenesis.

Links

PubMed PMC3202344 Online version:10.1002/dvdy.22713

Keywords

Animals; Fibroblast Growth Factor 10/genetics; Fibroblast Growth Factor 10/metabolism; Gene Expression Regulation, Developmental; In Situ Hybridization; PAX9 Transcription Factor/genetics; PAX9 Transcription Factor/metabolism; Palate/embryology; Palate/metabolism; Signal Transduction; Smad5 Protein/genetics; Smad5 Protein/metabolism; Transcription Factors/genetics; Transcription Factors/metabolism; Transforming Growth Factor beta2/genetics; Transforming Growth Factor beta2/metabolism; Zebrafish; Zebrafish Proteins/genetics; Zebrafish Proteins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DANRE:F8W4A6

involved_in

GO:0060021: roof of mouth development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-111102-1

P

Seeded From UniProt

complete

DANRE:K7DYI1

involved_in

GO:0060021: roof of mouth development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-111102-2

P

Seeded From UniProt

complete

DANRE:Q4VBV7

involved_in

GO:0060021: roof of mouth development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-081021-3

P

Seeded From UniProt

complete

DANRE:Q7SZV4

involved_in

GO:0060021: roof of mouth development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-111102-1

P

Seeded From UniProt

complete

DANRE:Q800L8

involved_in

GO:0060021: roof of mouth development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-081021-3

P

Seeded From UniProt

complete

DANRE:Q8AY90

involved_in

GO:0060021: roof of mouth development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-081021-3

P

Seeded From UniProt

complete

DANRE:Q98865

involved_in

GO:0060021: roof of mouth development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-111102-2

P

Seeded From UniProt

complete

DANRE:Q98866

involved_in

GO:0060021: roof of mouth development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-111102-2

P

Seeded From UniProt

complete

DANRE:SMAD5

involved_in

GO:0060021: roof of mouth development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-111206-1

P

Seeded From UniProt

complete


See also

References

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