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PMID:22011202

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Citation

Maragh, S, Miller, RA, Bessling, SL, McGaughey, DM, Wessels, MW, de Graaf, B, Stone, EA, Bertoli-Avella, AM, Gearhart, JD, Fisher, S and McCallion, AS (2011) Identification of RNA binding motif proteins essential for cardiovascular development. BMC Dev. Biol. 11:62

Abstract

We recently identified Rbm24 as a novel gene expressed during mouse cardiac development. Due to its tightly restricted and persistent expression from formation of the cardiac crescent onwards and later in forming vasculature we posited it to be a key player in cardiogenesis with additional roles in vasculogenesis and angiogenesis.

Links

PubMed PMC3277282 Online version:10.1186/1471-213X-11-62

Keywords

Animals; Animals, Genetically Modified; Binding Sites; Cardiovascular System/embryology; Embryo, Nonmammalian/metabolism; Gene Expression Regulation, Developmental; Morphogenesis/genetics; RNA/metabolism; RNA-Binding Proteins/genetics; RNA-Binding Proteins/metabolism; Zebrafish/embryology; Zebrafish/genetics; Zebrafish Proteins/genetics; Zebrafish Proteins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DANRE:E9QCG4

involved_in

GO:0001947: heart looping

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-120111-2

P

Seeded From UniProt

complete

DANRE:E9QCG4

involved_in

GO:0003229: ventricular cardiac muscle tissue development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-120111-2

P

Seeded From UniProt

complete

DANRE:E9QCG4

involved_in

GO:0003228: atrial cardiac muscle tissue development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-120111-2

P

Seeded From UniProt

complete

DANRE:E9QCG4

involved_in

GO:0072359: circulatory system development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-120111-1,ZFIN:ZDB-MRPHLNO-120111-2

P

Seeded From UniProt

complete

DANRE:F1Q8E8

involved_in

GO:0001947: heart looping

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-120111-2

P

Seeded From UniProt

complete

DANRE:F1Q8E8

involved_in

GO:0003229: ventricular cardiac muscle tissue development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-120111-2

P

Seeded From UniProt

complete

DANRE:F1Q8E8

involved_in

GO:0003228: atrial cardiac muscle tissue development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-120111-2

P

Seeded From UniProt

complete

DANRE:F1Q8E8

involved_in

GO:0072359: circulatory system development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-120111-1,ZFIN:ZDB-MRPHLNO-120111-2

P

Seeded From UniProt

complete

DANRE:Q29RC2

involved_in

GO:0001947: heart looping

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-120111-2

P

Seeded From UniProt

complete

DANRE:Q29RC2

involved_in

GO:0003229: ventricular cardiac muscle tissue development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-120111-2

P

Seeded From UniProt

complete

DANRE:Q29RC2

involved_in

GO:0003228: atrial cardiac muscle tissue development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-120111-2

P

Seeded From UniProt

complete

DANRE:Q29RC2

involved_in

GO:0072359: circulatory system development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-120111-1,ZFIN:ZDB-MRPHLNO-120111-2

P

Seeded From UniProt

complete

DANRE:RBM24

involved_in

GO:0001947: heart looping

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-120111-1

P

Seeded From UniProt

complete

DANRE:RBM24

involved_in

GO:0003228: atrial cardiac muscle tissue development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-120111-1

P

Seeded From UniProt

complete

DANRE:RBM24

involved_in

GO:0072359: circulatory system development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-120111-1,ZFIN:ZDB-MRPHLNO-120111-2

P

Seeded From UniProt

complete


See also

References

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