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PMID:21949834

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Citation

Mouillesseaux, K and Chen, JN (2011) Mutation in utp15 disrupts vascular patterning in a p53-dependent manner in zebrafish embryos. PLoS ONE 6:e25013

Abstract

Angiogenesis is the process by which the highly branched and functional vasculature arises from the major vessels, providing developing tissues with nutrients, oxygen, and removing metabolic waste. During embryogenesis, vascular patterning is dependent on a tightly regulated balance between pro- and anti-angiogenic signals, and failure of angiogenesis leads to embryonic lethality. Using the zebrafish as a model organism, we sought to identify genes that influence normal vascular patterning.

Links

PubMed PMC3176792 Online version:10.1371/journal.pone.0025013

Keywords

Animals; Animals, Genetically Modified; Apoptosis; Blood Vessels/embryology; Blood Vessels/metabolism; Cloning, Molecular; Embryo, Nonmammalian/cytology; Embryo, Nonmammalian/metabolism; Embryonic Development; Gene Expression Regulation, Developmental; In Situ Hybridization; Mutation/genetics; Neovascularization, Physiologic; Phenotype; RNA, Messenger/genetics; Real-Time Polymerase Chain Reaction; Signal Transduction; Tumor Suppressor Protein p53/genetics; Tumor Suppressor Protein p53/metabolism; Zebrafish/embryology; Zebrafish/genetics; Zebrafish/metabolism; Zebrafish Proteins/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DANRE:P53

involved_in

GO:0016525: negative regulation of angiogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-111020-9,ZFIN:ZDB-MRPHLNO-070126-7

P

Seeded From UniProt

complete

DANRE:UTP15

involved_in

GO:0045766: positive regulation of angiogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-111020-9,ZFIN:ZDB-MRPHLNO-070126-7

P

Seeded From UniProt

complete


See also

References

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