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PMID:21838932

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Citation

Kim, HT, So, JH, Jung, SH, Ahn, DG, Koh, W, Kim, NS, Kim, SH, Lee, S and Kim, CH (2011) Cug2 is essential for normal mitotic control and CNS development in zebrafish. BMC Dev. Biol. 11:49

Abstract

We recently identified a novel oncogene, Cancer-upregulated gene 2 (CUG2), which is essential for kinetochore formation and promotes tumorigenesis in mammalian cells. However, the in vivo function of CUG2 has not been studied in animal models.

Links

PubMed PMC3171718 Online version:10.1186/1471-213X-11-49

Keywords

Amino Acid Sequence; Animals; Apoptosis/genetics; Cell Transformation, Neoplastic/metabolism; Central Nervous System/embryology; Central Nervous System/metabolism; Chromosome Aberrations/embryology; Chromosomes/genetics; Gene Expression Regulation, Developmental; Kinetochores/metabolism; Mitosis/physiology; Mitotic Spindle Apparatus/genetics; Mitotic Spindle Apparatus/pathology; Morpholinos/genetics; Neurodegenerative Diseases/genetics; Neurogenesis/genetics; Nuclear Proteins/genetics; Nuclear Proteins/metabolism; RNA Interference; RNA, Small Interfering; Sequence Alignment; Zebrafish/embryology; Zebrafish/genetics; Zebrafish/metabolism; Zebrafish Proteins/genetics; Zebrafish Proteins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DANRE:A0A0R4ISL4

involved_in

GO:0007417: central nervous system development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-111025-2

P

Seeded From UniProt

complete

DANRE:A0A0R4ISL4

involved_in

GO:0007417: central nervous system development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-111025-1

P

Seeded From UniProt

complete

DANRE:A0A0R4ISL4

involved_in

GO:0007346: regulation of mitotic cell cycle

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-111025-2

P

Seeded From UniProt

complete

DANRE:A0A0R4IXK5

involved_in

GO:0007417: central nervous system development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-111025-2

P

Seeded From UniProt

complete

DANRE:A0A0R4IXK5

involved_in

GO:0007417: central nervous system development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-111025-1

P

Seeded From UniProt

complete

DANRE:A0A0R4IXK5

involved_in

GO:0007346: regulation of mitotic cell cycle

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-111025-2

P

Seeded From UniProt

complete


See also

References

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